Impact of Emerging Pollutants in Health: a Study on Biomimetic Membranes

• Grant number: 17/06534-8
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2018
• End date: March 31, 2020
• Field of knowledge: Physical Sciences and Mathematics - Physics - Condensed Matter Physics
• Principal Investigator: Priscila Alessio Constantino
• Grantee: Priscila Alessio Constantino
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil

Abstract

Contaminated water is considered a major cause of diseases in human being and animals. Currently, so-called emerging contaminants were highlighted in studies of water analyzes for consumption worldwide. These contaminants are a class of compounds comprising pharmaceuticals, personal care products, industrial products, natural and synthetic hormones, illegal drugs, pesticides, nanomaterials, among others. The World Health Organization admits that there is a knowledge gap considering the risks associated with exposure to low drug concentrations in the long term. In particular, a need exists to study the "cocktail" and "additive" effects, i.e., how different drugs or other emerging contaminants may interact each other to produce adverse effects. In this context, the development of this Regular Research project has as main objective to elucidate the processes occurring in biomimetic membranes (mimetic models of cell membranes) due to the exposure to emerging pollutants. The Langmuir and giant unilamellar vesicles techniques are used to mimic the biological membrane in the absence and presence of emerging pollutants. The reflection and absorption spectroscopy in the infrared polarization modulation (PM-IRRAS) and confocal fluorescence microscopy will be used as principal tools to obtain chemical and morphological information of interactions at molecular level between the biomimetic membranes and emerging pollutants (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARLIN, CIBELY S.; MAXIMINO, MATEUS D.; PEREIRA, MATHEUS S.; ALESSIO, PRISCILA. Polyphenol Detection in Mate Tea Samples Using Iron Tetrasulfonated Phthalocyanine Modified Screen-Printed Electrode. IEEE SENSORS JOURNAL, v. 19, n. 22, p. 10686-10692, NOV 15 2019. (17/15019-0, 17/06534-8)

MAXIMINO, MATEUS D.; CONSTANTINO, CARLOS J. L.; OLIVEIRA, JR., OSVALDO N.; ALESSIO, PRISCILA. Synergy in the interaction of amoxicillin and methylene blue with dipalmitoyl phosphatidyl choline (DPPC) monolayers. Applied Surface Science, v. 476, p. 493-500, MAY 15 2019. (13/14262-7, 17/06534-8)

KAVAZOI, HENRY S.; MARTIN, CIBELY S.; ALESSIO, PRISCILA. Comparative study of tetrasulfonated phthalocyanine modified screen-printed electrodes in paraquat. Synthetic Metals, v. 284, p. 10-pg., 2022-03-01. (18/22214-6, 17/15019-0, 14/50869-6, 17/06534-8)

KAVAZOI, HENRY S.; MARTIN, CIBELY S.; MAXIMINO, MATEUS D.; PEREIRA, MATHEUS S.; RODRIGUEZ-MENDEZ, MARIA L.; ALESSIO, PRISCILA. Controlling supramolecular structures in iron tetrasulfonated phthalocyanine films through pH variation: implications for thin-film device performance. Physical Chemistry Chemical Physics, v. N/A, p. 9-pg., 2023-09-20. (21/14235-6, 17/15019-0, 18/22214-6, 17/06534-8)

FERNANDES, JOSE DIEGO; MAXIMINO, MATEUS D.; BRAUNGER, MARIA LUISA; PEREIRA, MATHEUS S.; OLIVATI, CLARISSA DE ALMEIDA; CONSTANTINO, CARLOS J. L.; ALESSIO, PRISCILA. Supramolecular architecture and electrical conductivity in organic semiconducting thin films. Physical Chemistry Chemical Physics, v. 22, n. 24, p. 13554-13562, JUN 28 2020. (17/06534-8, 10/20094-1, 14/50869-6)

FURINI, LEONARDO N.; COSTA, GABRIEL; LEOPOLDO CONSTANTINO, CARLOS JOSE; ALESSIO, PRISCILA. pH-responsive Ag@PAH nanoparticles applied in SERS. Materials Letters, v. 277, OCT 15 2020. (18/14692-5, 17/06534-8)

MARTIN, CIBELY S.; RUBIRA, RAFAEL J. G.; SILVA, JAQUELINE N.; ALESSIO, PRISCILA. Role of Iron Phthalocyanine Coordination in Catecholamines Detection. SURFACES, v. 4, n. 4, p. 323-335, DEC 2021. (17/15019-0, 14/50869-6, 17/06534-8, 20/05423-0)

MAXIMINO, MATEUS D.; SILVA, CARLA Y.; CAVALCANTE, DALITA G. S. M.; MARTIN, CIBELY S.; JOB, ALDO E.; OLIVEIRA, JR., OSVALDO N.; ALESSIO, PRISCILA. Consequences of the exposure to bisphenol A in cell membrane models at the molecular level and hamster ovary cells viability. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 203, JUL 2021. (18/22214-6, 17/06534-8, 17/15019-0)

MAXIMINO, MATEUS D.; MARTIN, CIBELY S.; ALESSIO, PRISCILA. Bisphenol A exposure induces multiple effects in DOPC membrane models. JOURNAL OF MOLECULAR LIQUIDS, v. 359, p. 9-pg., 2022-08-01. (18/22214-6, 17/15019-0, 21/14235-6, 17/06534-8)