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Effect of photobiostimulation on different peripheral neuropathies in rats.

Grant number: 17/05218-5
Support Opportunities:Regular Research Grants
Duration: April 01, 2018 - March 31, 2020
Field of knowledge:Biological Sciences - Morphology - Anatomy
Principal Investigator:Marucia Chacur
Grantee:Marucia Chacur
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The technique of photobiostimulation, use of light as therapy, is a non-invasive method that has been shown both in basic and in clinical research to be effective in reducing pain sensitivity and consequently improving the quality of life of patients with neuropathic pain. The present study aims to examine the effects of low level laser (LLLT) on pain sensitivity and sciatic nerve repair induced by peripheral neuropathies such as chronic constrictive injury (CCI) and type 1 diabetes mellitus in wistar rats, Using in vitro assays and behavioral analysis. At the end of treatment with photobiostimulation and behavioral tests, the animals will be euthanized and tissues such as sciatic nerve and dorsal root ganglia (L4-L6) will be removed for further analysis. Our preliminary and partially published results point to an improvement in the nococeptive response in the LLLT group when compared to the untreated group in both experimental models. Based on our results, we can suggest that LLLT treatment improves nociception induced by neuropathic lesions and induces an improvement in sciatic nerve regeneration. Furthermore, studies demonstrate that laser light penetrates in the tissue where it is absorbed by chromophores, resulting in an increase in cellular metabolism through the increase of ATP synthesis by mitochondria. However, there is a lack of studies demonstrating the involvement of this technique in the maintenance of neuropathic pain, the involvement of neurotrophic factors, the repair of peripheral nerves and the possible role of mitochondria. With this, our main objective is to better understand the mechanisms involved in photobiostimulation using two neuropathic lesion models in experimental animals. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ROCHA, P. A.; FERREIRA, A. F. B.; DA SILVA, J. T.; ALVES, A. S.; MARTINS, D. O.; BRITTO, L. R. G.; CHACUR, M.. Effects of selective inhibition of nNOS and iNOS on neuropathic pain in rats. Molecular and Cellular Neuroscience, v. 105, . (11/22268-0, 17/05218-5)
HELOU, AMMIR YACOUB; MARTINS, DANIEL OLIVEIRA; ARRUDA, BRUNA PETRUCELLI; DE SOUZA, MATHEUS CERUSSI; CRUZ-OCHOA, NATALIA ANDREA; NOGUEIRA, MARIA INES; CHACUR, MARUCIA. Neonatal anoxia increases nociceptive response in rats: Sex differences and lumbar spinal cord and insula alterations. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, v. 81, n. 8, . (15/18415-8, 14/22313-3, 17/05218-5, 15/24256-0)
MARINA RAMOS; CAIO A. H. CRUZ; MOISES F. LAURENTINO; HAZEM ADEL ASHMAWI; FABIO M. SANTOS; MARUCIA CHACUR. Effects of neural mobilization on individuals with chronic low back pain. BrJP, n. ahead, p. -, . (17/05218-5)
BINDA, K. H.; REAL, C. C.; FERREIRA, A. F. F.; BRITTO, L. R.; CHACUR, M.. Antinociceptive effects of treadmill exercise in a rat model of Parkinson's disease: The role of cannabinoid and opioid receptors. Brain Research, v. 1727, . (17/05218-5, 17/26821-1)
RODRIGUES, ALEX DE FREITAS; MARTINS, DANIEL DE OLIVEIRA; CHACUR, MARUCIA; LUZ, JOAO GUALBERTO C.. The effectiveness of photobiomodulation in the management of temporomandibular pain sensitivity in rats: behavioral and neurochemical effects. Lasers in Medical Science, v. 35, n. 2, p. 447-453, . (17/05218-5)
MARINA RAMOS; CAIO A. H. CRUZ; MOISES F. LAURENTINO; HAZEM ADEL ASHMAWI; FABIO M. SANTOS; MARUCIA CHACUR. Efeito da mobilização neural em indivíduos com dor lombar crônica. BrJP, v. 3, n. 3, p. 205-212, . (17/05218-5)

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