Optimization, synthesis and pharmacological evaluation of dual hybrid compounds useful to treat the symptoms of sickle cell disease

• Grant number: 07/56115-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: December 01, 2007
• End date: March 31, 2009
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Chung Man Chin
• Grantee: Jean Leandro dos Santos
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DOS SANTOS, JEAN LEANDRO; LANARO, CAROLINA; LIMA, LIDIA MOREIRA; GAMBERO, SHELEY; FRANCO-PENTEADO, CARLA FERNANDA; AEXANDRE-MOREIRA, MAGNA SUZANA; WADE, MARLENE; YERIGENAHALLY, SHOBHA; KUTLAR, ABDULLAH; MEILER, STEFFEN E.; et al. Design, Synthesis, and Pharmacological Evaluation of Novel Hybrid Compounds To Treat Sickle Cell Disease Symptoms. Journal of Medicinal Chemistry, v. 54, n. 16, p. 5811-5819, AUG 25 2011. (07/56115-0, 10/12495-6)

SANTOS, JEAN L.; YAMASAKI, PAULO R.; CHIN, CHUNG MAN; TAKASHI, CELIO H.; PAVAN, FERNANDO R.; LEITE, CLARICE Q. F.. Synthesis and in vitro anti Mycobacterium tuberculosis activity of a series of phthalimide derivatives. Bioorganic & Medicinal Chemistry, v. 17, n. 11, p. 3795-3799, JUN 1 2009. (07/56115-0, 08/10390-2)

CHUNG, MAN CHIN; DOS SANTOS, JEAN LEANDRO; OLIVEIRA, EDNIR VIZIOLI; BLAU, LORENA; MENEGON, RENATO FARINA; PECCININI, ROSANGELA GONCALVES. Synthesis, ex Vivo and in Vitro Hydrolysis Study of an Indoline Derivative Designed as an Anti-Inflammatory with Reduced Gastric Ulceration Properties. Molecules, v. 14, n. 9, p. 3187-3197, SEP 2009. (07/56115-0)

DOS SANTOS, JEAN LEANDRO; LANARO, CAROLINA; CHELUCCI, RAFAEL CONSOLIN; GAMBERO, SHELEY; BOSQUESI, PRISCILA LONGHIN; REIS, JULIANA SANTANA; LIMA, LIDIA MOREIRA; CERECETTO, HUGO; GONZALEZ, MERCEDES; COSTA, FERNANDO FERREIRA; et al. Design, Synthesis, and Pharmacological Evaluation of Novel Hybrid Compounds to Treat Sickle Cell Disease Symptoms. Part II: Furoxan Derivatives. Journal of Medicinal Chemistry, v. 55, n. 17, p. 7583-7592, SEP 13 2012. (07/56115-0, 10/12495-6)

DOS SANTOS, JEAN LEANDRO; VARANDA, ELIANA A.; LIMA, LIDIA MOREIRA; CHIN, CHUNG MAN. Mutagenicity of New Lead Compounds to Treat Sickle Cell Disease Symptoms in a Salmonella/Microsome Assay. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 11, n. 2, p. 779-788, FEB 2010. (07/56115-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SANTOS, Jean Leandro dos. Síntese e avaliação farmacológica de protótipos candidatos à fármacos para o tratamento dos sintomas da anemia falciforme. 2009. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Farmacêuticas. Araraquara Araraquara.