EFFECT OF INTERMITTENT ADMINISTRATION OF hPTH(1-34) ON ALVEOLAR WOUND HEALING OF RAT MOLARS.

• Grant number: 08/05212-8
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): October 01, 2008
• Effective date (End): February 29, 2012
• Field of knowledge: Biological Sciences - Morphology - Histology
• Principal Investigator: Pedro Duarte Novaes
• Grantee: Juliana dos Santos Neves
• Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil

Abstract

The parathyroid hormone (PTH) is a polypeptide hormone secreted by the parathyroid gland in response to low calcium in the blood. PTH is considered a catabolic agent for the skeleton, however the intermittent administration of this hormone promotes an increase of bone mass. Its mechanism of action is still not well understood, although it is known that PTH regulates gene expression in the osteoblasts, supporting synthesis of matrix proteins required for new bone formation, proteins regulating osteoclasts differentiation, and proteins associated with matrix degradation and turnover. Nowadays, PTH it is used to treat osteoporosis because this capacity to stimulate bone formation, however, few studies have been evaluated the effects of PTH on metabolism of bones of the face, and it can produce a favorable effect in repair processes. An interesting model for studying bone repair is the socket healing process after tooth extraction, considering the absence of cartilage formation, the short period needed, and its clinical relevance. Furthermore, the alveolar wound healing process has been extensively studied and its sequence of events is well understood; being the rat healing sequence similar to the human, however, faster. The aim of the present study it is analyzes the influence of intermittent administration of PTH on alveolar wound healing process after mandibular molars extraction in rats, as well as its effect on expression of some genes involved in this process.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

NEVES, Juliana dos Santos. Effect of intermittent administration of hPTH(1-34) on the early stages of alveolar wound healing after rat molar extraction. 2012. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba Piracicaba, SP.