Expression of genes CCR1, TAGLN and PTEN in human endometrium of women with endometriosis compared to endometrium of women without endometriosis

• Grant number: 09/03569-9
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): August 01, 2009
• Effective date (End): July 31, 2011
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Rui Alberto Ferriani
• Grantee: Gabriela dos Santos Hidalgo
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Endometriosis is an enigmatic disease, has a benign pathology nature, is estrogen-dependent, and is pretty aggressive, affecting 10 to 15% of women in a reproductive age. Is defined by the presence of an ectopic implant, a tissue that is histologically alike to women's endometrium with and without endometriosis (ectopic). It is a complex and multifactorial disease that needs mechanisms for the implant and maintenance of this ectopic tissue: an immunological system dysfunction, gathering, invasion, proliferation and cellular differentiation mechanisms, modified rates of apoptosis, angiogenesis, etc. However, studies of genes related to these processes with CCR1 (inflammatory process), TAGLN (transformation marker) and PTEN (tumoral suppressor), have great meaning to understand cellular malfunction of the endometrial implants. This study objective is to analyze the genomic expression of CCR1, TAGLN and PTEN, in ectopic endometrium samples of 40 women with endometriosis, 20 in the proliferative phase and other 20 on the secretions phase, and in 30 controls (women's endometrium without endometriosis), 15 in proliferative phase and 15 on secretions phase