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Expression of genes CCR1, TAGLN and PTEN in human endometrium of women with endometriosis compared to endometrium of women without endometriosis

Grant number: 09/03569-9
Support type:Scholarships in Brazil - Master
Effective date (Start): August 01, 2009
Effective date (End): July 31, 2011
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Rui Alberto Ferriani
Grantee:Gabriela dos Santos Hidalgo
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Endometriosis is an enigmatic disease, has a benign pathology nature, is estrogen-dependent, and is pretty aggressive, affecting 10 to 15% of women in a reproductive age. Is defined by the presence of an ectopic implant, a tissue that is histologically alike to women's endometrium with and without endometriosis (ectopic). It is a complex and multifactorial disease that needs mechanisms for the implant and maintenance of this ectopic tissue: an immunological system dysfunction, gathering, invasion, proliferation and cellular differentiation mechanisms, modified rates of apoptosis, angiogenesis, etc. However, studies of genes related to these processes with CCR1 (inflammatory process), TAGLN (transformation marker) and PTEN (tumoral suppressor), have great meaning to understand cellular malfunction of the endometrial implants. This study objective is to analyze the genomic expression of CCR1, TAGLN and PTEN, in ectopic endometrium samples of 40 women with endometriosis, 20 in the proliferative phase and other 20 on the secretions phase, and in 30 controls (women's endometrium without endometriosis), 15 in proliferative phase and 15 on secretions phase