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Evaluation MAGP-1's function in neointimal formation.

Grant number: 09/03495-5
Support type:Scholarships in Brazil - Master
Effective date (Start): August 01, 2009
Effective date (End): February 28, 2011
Field of knowledge:Biological Sciences - Biochemistry - Chemistry of Macromolecules
Principal Investigator:Claudio Chrysostomo Werneck
Grantee:Tallita Vassequi da Silva
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

MAGP1 is a microfibril component. Many in vitro studies have shown MAGP1 interacts with fibrillin -1 and -2, tropoelastin and others. Although any pathology has been related to MAGP1 deficiency or gene mutations, zebra fish studies have shown that MAGP1 expression is critical for vascular development where changes are associated with decreased integrin/extracellular matrix interaction. Data obtained by our group using thrombus induction by photochemical model suggest MAGP1's importance in thrombus formation in mice, where MAGP1-deficient mice needed almost twice the time to form a thrombus. Data from literature show that MAGP1 can bind the active forms of BMP-7 and TGF ², which have been implicated in vascular disorders such as atherosclerosis and restenosis after angioplasty procedure. Preliminary data from our laboratory demonstrated that MAGP1-deficient mice undergo an angioplasty surgery model developed more neointima (restenosis) when compared with wild-type animals. Therefore, our goal is to verify the possible involvement of MAGP1 in the formation of neointima (by surgery angioplasty) in wild type and MAGP1-deficient mice.