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Evaluation on elastic fiber synthesis in cell culture obtained from fibrillin-1 defficient mice: Losartan's effect studies

Grant number: 10/19916-7
Support type:Regular Research Grants
Duration: March 01, 2011 - February 28, 2013
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Principal researcher:Claudio Chrysostomo Werneck
Grantee:Claudio Chrysostomo Werneck
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Assoc. researchers:Cristina Pontes Vicente ; Guilherme Gambogi Braga

Abstract

Fibrillin-1 is an important microfibril network component. Microfibrils are present in elastic fiber responsible for resilience and elastic properties from structures like lungs, skin and large vessels. Mutations in Fibrillin-1 gene are associated with Marfan's Syndrome. Marfan's Syndrome patients shown many different clinical manifestations in lungs, cardiovascular tract and eyes tissues. Marfan's models have been created to get better insights about this disease development. Recent studies from mice models have suggested an important role to unbalanced TGF beta activity promoting almost whole alterations found in those mice which might be rescued by losartan treatment. Our main goal is evaluate elastic fiber formation in cell culture obtained from fibrillin-1 defficient mice and verify TGF-beta expression levels as well as losartan's treatment effect on those cells. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ANTONIELLIS SILVEIRA, ANGELICA APARECIDA; DOMINICAL, VENINA MARCELA; VITAL, DAIANA MORELLI; FERREIRA, JR., WILSON ALVES; MARANHAO COSTA, FABIO TRINDADE; WERNECK, CLAUDIO C.; COSTA, FERNANDO FERREIRA; CONRAN, NICOLA. Attenuation of TNF-induced neutrophil adhesion by simvastatin is associated with the inhibition of Rho-GTPase activity, p50 activity and morphological changes. International Immunopharmacology, v. 58, p. 160-165, MAY 2018. Web of Science Citations: 1.
ANTONIELLIS SILVEIRA, ANGELICA APARECIDA; DOMINICAL, VENINA MARCELA; ALMEIDA, CAMILA BONONI; CHWEIH, HANAN; FERREIRA, JR., WILSON ALVES; VICENTE, CRISTINA PONTES; MARANHAO COSTA, FABIO TRINDADE; WERNECK, CLAUDIO C.; COSTA, FERNANDO FERREIRA; CONRAN, NICOLA. TNF induces neutrophil adhesion via formin-dependent cytoskeletal reorganization and activation of beta-integrin function. Journal of Leukocyte Biology, v. 103, n. 1, p. 87-98, JAN 2018. Web of Science Citations: 3.
VASSEQUI-SILVA, TALLITA; PEREIRA, DANIELLE SOUSA; NERY DIEZ, ANA CLAUDIA C.; BRAGA, GUILHERME G.; GODOY, JULIANA A.; MENDES, CAMILA B.; DOS SANTOS, LEONARDO; KRIEGER, JOSE E.; ANTUNES, EDSON; COSTA, FABIO T. M.; VICENTE, CRISTINA P.; WERNECK, CLAUDIO C. Losartan and captopril treatment rescue normal thrombus formation in microfibril associated glycoprotein-1 (MAGP1) deficient mice. THROMBOSIS RESEARCH, v. 138, p. 7-15, FEB 2016. Web of Science Citations: 3.
CARNEIRO, GIANE D.; GODOY, JULIANA A. P.; WERNECK, CLAUDIO C.; VICENTE, CRISTINA P. Differentiation of C57/BL6 mice bone marrow mononuclear cells into early endothelial progenitors cells in different culture conditions. Cell Biology International, v. 39, n. 10, p. 1138-1150, OCT 2015. Web of Science Citations: 5.
DAMICO, DANIELA C. S.; VASSEQUI-SILVA, T.; TORRES-HUACO, F. D.; NERY-DIEZ, A. C. C.; DE SOUZA, R. C. G.; DA SILVA, S. L.; VICENTE, C. P.; MENDES, C. B.; ANTUNES, E.; WERNECK, C. C.; MARANGONI, SERGIO. LmrTX, a basic PLA(2) (D49) purified from Lachesis muta rhombeata snake venom with enzymatic-related antithrombotic and anticoagulant activity. Toxicon, v. 60, n. 5, p. 773-781, OCT 2012. Web of Science Citations: 13.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.