Central mechanisms of musculoskeletal pain induced by carrageenin in rats.

• Grant number: 09/12244-6
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2010
• End date: February 29, 2012
• Field of knowledge: Biological Sciences - Morphology - Anatomy
• Principal Investigator: Marucia Chacur
• Grantee: Milena Fernandes de Freitas
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Chemical stimulation of nociceptive afferent fibers through the injection of different substances has been studied in diferents models of muscle pain in animals. It is known that musculoskeletal pain is involved in the modulation and maintenance of the afferent fibers of group III and IV after muscle inflammation. Carrageenan is one of the agents that produce inflammation and is often used in models of muscle pain. Our goal is to observe, to understand and to explore in greater detail the involvement of glial cells (astrocytes and microglia), pro-inflammatory cytokines, prostanoids and nitric oxide after induction of acute myositis and correlate with nociceptive behavioral models. Still, will be assessed the expression of these mediators in the central spinal cord and dorsal root ganglion, using the Western blot method. Such investigations may be a totally new approach to try to understand why, how and what are some of the mediators involved in this kind of pain. Thus, the data obtained in this project will elucidate the mechanisms involved in musculoskeletal pain, which are of difficult treatment and of great clinical relevance.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FREITAS, Milena Fernandes de. Central mechanisms of musculoskeletal pain induced by carrageenan in rats.. 2012. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.