Melatonin, the darkness hormone, is also a modulator of the immune system, and it can be produced either by the pineal gland or immune competent cells. Taking into account the switch between pineal and peripheral production of melatonin during the mounting of an inflammatory response, our laboratory proposed the existence of an immune-pineal axis, which involves a bidirectional interaction of the gland with the immune system. In this project we intend to evaluate the effect of melatonin on cultured cerebellar cells challenged by injured agents, as well as the ability of glial cells to produce melatonin. We will focus in the nuclear factor kappa B (NFKB) pathway, which is pivotal for mounting inflammatory responses, and neuronal survival. This project will contribute for understanding the effect of melatonin on neuronal cells and providing evidence for its beneficial and collateral effects.
News published in Agência FAPESP Newsletter about the scholarship: