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Immune-pineal axis: modulatory effect of melatonin on the NFKB pathway in cerebellar cells cultures

Grant number: 09/17800-4
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2010
Effective date (End): November 30, 2013
Field of knowledge:Biological Sciences - Physiology - General Physiology
Principal Investigator:Regina Pekelmann Markus
Grantee:Daiane Gil Franco
Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:07/07871-6 - Imune-pineal Axis: injury shifts melatonin production from endocrine to paracrine, AP.TEM


Melatonin, the darkness hormone, is also a modulator of the immune system, and it can be produced either by the pineal gland or immune competent cells. Taking into account the switch between pineal and peripheral production of melatonin during the mounting of an inflammatory response, our laboratory proposed the existence of an immune-pineal axis, which involves a bidirectional interaction of the gland with the immune system. In this project we intend to evaluate the effect of melatonin on cultured cerebellar cells challenged by injured agents, as well as the ability of glial cells to produce melatonin. We will focus in the nuclear factor kappa B (NFKB) pathway, which is pivotal for mounting inflammatory responses, and neuronal survival. This project will contribute for understanding the effect of melatonin on neuronal cells and providing evidence for its beneficial and collateral effects. (AU)

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FRANCO, Daiane Gil. The cellular context determines the effect of melatonin on the survival of cerebellar granule cells. 2014. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Biociências (IBIOC/SB) São Paulo.

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