Morita-Baylis-Hillma in synthesis: structural diversity and biological evaluation of spirocyclohexadienones

• Grant number: 09/18390-4
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: March 01, 2010
• End date: February 28, 2014
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Fernando Antonio Santos Coelho
• Grantee: Lucimara Júlio Martins
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 09/51602-5 - Chemical biology: new natural and synthetic molecular targets against cancer, structural studies, biological evaluation and mode of action, AP.TEM

Abstract

Recently we have developed a new methodology to prepare spirocyclohexadienones from Morita-Baylis-Hillman adducts. This method is based on the use of a Heck reaction associated to a phenolic oxidation mediated by hypervalent iodine reagents. This phD roject has as purpose increasing the scope of this method and prepare new spirocycloexadienones with different structural diversity. This structural diversity will allow us to evaluate the bactericide and anti-tumoral activities of these compounds. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARTINS, LUCIMARA J.; FERREIRA, BRUNO R. V.; ALMEIDA, WANDA P.; LANCELLOTTI, MARCELO; COELHO, FERNANDO. An easy access to halogenated and non-halogenated spiro-hexadienones. Tetrahedron Letters, v. 55, n. 38, p. 5264-5267, SEP 17 2014. (09/51602-5, 09/18390-4, 11/20033-5)

MARTINS, LUCIMARA JULIO; SIMONI, DEBORAH DE ALENCAR; APARICIO, RICARDO; COELHO, FERNANDO. Crystal structure of methyl 2-(2H-1,3-benzodioxol-5-yl)-7,9-dibromo-8-oxo1-oxaspiro[4.5]deca-2,6,9-triene-3-carboxylate. ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, v. 70, p. 9-pg., 2014-12-01. (09/51602-5, 09/18390-4)

MARTINS, LUCIMARA JULIO; SIMONI, DEBORAH DE ALENCAR; APARICIO, RICARDO; COELHO, FERNANDO. Crystal structure of 3-methoxycarbonyl-2-(4-methoxypheny1)-8-oxo-1-azaspiro-[4.5]deca-1,6,9-trien-1-ium-1-olate. ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, v. 70, p. 9-pg., 2014-11-01. (09/51602-5, 09/18390-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MARTINS, Lucimara Júlio. Morita-Baylis-Hillman em síntese: diversidade estrutural e avaliação biológica de espiro-hexadienonas. 2014. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Química Campinas, SP.