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Study of biochemical variations and genotoxicity induced by the mixture of contaminants in tilapia (Oreochromis niloticus), as biomarkers of environmental contamination.

Grant number: 09/18486-1
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): November 01, 2010
Effective date (End): February 28, 2013
Field of knowledge:Biological Sciences - Biochemistry - Metabolism and Bioenergetics
Principal Investigator:Eduardo Alves de Almeida
Grantee:Aline Cristina Ferreira Rodrigues
Host Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil


Currently the aquatic biota is subject to a wide mix of xenobiotic compounds that are discarded in the environment. These compounds, produced in large-scale consumption of modern society, may have high potential cytotoxic, mutagenic and carcinogenic. In this context stand pesticides, polycyclic aromatic hydrocarbons (PAHs), estrogen disruptors and heavy metals.Biomonitoring studies in aquatic organisms are very promising, and fish as sentinels to show extremely sensitive to environmental disturbances caused by anthropogenic activities. This study aims to evaluate in Oreochromis niloticus, biochemical responses after controlled exposure to mixtures of organophosphate and pyrethroid pesticides, benzo (a) pyrene (PAH) and 17²-estradiol (an endocrine disruptor). Will be analyzed after 5 days of treatment, brain, liver and gills, the activity of the enzyme acetylcholinesterase, carboxylesterase, glutathione S-transferase, UDP-glicurosiltransferase, EROD, BROD, PROD, and levels of DNA damage (8-oxodGuo), lipid peroxidation and metallothioneins, and the presence of micronuclei in erythrocytes, intending thereby a better understanding of the interaction of the effects of contaminants on fish health. Finally, a detailed study of biomonitoring along the river Tiet /SP, on Araçatuba city. They will be examined biomarkers in fish exposed to water from different parts of the river in a region with intense sulcro-ethanol, livestock and several condominiums with nautical leisure activities on the river. This is an attempt to evaluate the possible effects of human activities on water quality in the region.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
RODRIGUES, Aline Cristina Ferreira. Estudo de variações bioquímicas e genotoxicidade induzidas por mistura de contaminantes em tilápia (Oreochromis niloticus), como biomarcadores de contaminação ambiental. 2014. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Biociências Letras e Ciências Exatas. São José do Rio Preto São José do Rio Preto.

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