Production of biodegradable scaffolds of polysaccharide hydrogel for cell growth

• Grant number: 10/13034-2
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: January 01, 2011
• End date: July 31, 2013
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Denise Freitas Siqueira Petri
• Grantee: Vânia Aparecida Blasques Bueno Silva
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Hydrogels from polysaccharides, due to its properties, as biocompatibility, biodegradability and ability to suffer chemical derivatization to generate new compounds with improved properties have increased interest in applications as scaffolds for cell growth.The objectives of this project are to obtain hydrogels scaffolods from polysaccharides as xanthan, starch and their blends, for growth of epithelial cells and nerve cells. The materials will be characterized in terms of morphology, mechanical, thermal and surface properties, and its capacity for adhesion, proliferation and differentiation of mentioned cells.The hydrogels will also be modified with differentiation and growth factors to increase their ability to function as a scaffold for cell growth. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BUENO, VANIA BLASQUES; SIQUEIRA PETRI, DENISE FREITAS. Xanthan hydrogel films: Molecular conformation, charge density and protein carriers. Carbohydrate Polymers, v. 101, p. 897-904, JAN 30 2014. (10/13034-2)

BUENO, VANIA BLASQUES; SILVA, ANIELLE MARTINS; SOUZA BARBOSA, LEANDRO RAMOS; CATALANI, LUIZ HENRIQUE; TEIXEIRA-NETO, ERICO; CORNEJO, DANIEL REINALDO; SIQUEIRA PETRI, DENISE FREITAS. Hybrid composites of xanthan and magnetic nanoparticles for cellular uptake. CHEMICAL COMMUNICATIONS, v. 49, n. 85, p. 9911-9913, 2013. (10/51219-4, 10/13034-2)

BUENO, VANIA BLASQUES; BENTINI, RICARDO; CATALANI, LUIZ HENRIQUE; SIQUEIRA PETRI, DENISE FREITAS. Synthesis and swelling behavior of xanthan-based hydrogels. Carbohydrate Polymers, v. 92, n. 2, p. 1091-1099, FEB 15 2013. (10/13034-2)

BUENO, VANIA BLASQUES; BENTINI, RICARDO; CATALANI, LUIZ HENRIQUE; BARBOSA, LEANDRO R. S.; SIQUEIRA PETRI, DENISE FREITAS. Synthesis and characterization of xanthan-hydroxyapatite nanocomposites for cellular uptake. Materials Science & Engineering C-Materials for Biological Applications, v. 37, p. 195-203, APR 1 2014. (10/13034-2, 11/21442-6)

GLASER, TALITA; BUENO, VANIA B.; CORNEJO, DANIEL R.; PETRI, DENISE F. S.; ULRICH, HENNING. Neuronal adhesion, proliferation and differentiation of embryonic stem cells on hybrid scaffolds made of xanthan and magnetite nanoparticles. Biomedical Materials, v. 10, n. 4, AUG 2015. (10/13034-2, 12/50880-4)

BUENO, VANIA BLASQUES; TAKAHASHI, SUELEN HARUMI; CATALANI, LUIZ HENRIQUE; CORDOBA DE TORRESI, SUSANA INES; SIQUEIRA PETRI, DENISE FREITAS. Biocompatible xanthan/polypyrrole scaffolds for tissue engineering. Materials Science & Engineering C-Materials for Biological Applications, v. 52, p. 121-128, JUL 1 2015. (10/13034-2)