Utilization of cellulose nanocrystals in the production of polymer nanocomposites for applications in the medical area

• Grant number: 13/27064-9
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2014
• End date: December 31, 2016
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
• Principal Investigator: Ana Paula Lemes
• Grantee: Ana Paula Lemes
• Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Federal de São Paulo (UNIFESP). Campus São José dos Campos. São José dos Campos , SP, Brazil
• Associated researchers: Dayane Batista Tada ; Thaís Larissa do Amaral Montanheiro

Abstract

The search for biodegradable hydrogels and scaffolds that can provide mechanical support and suitable biodegradation time for the recovery of damaged tissue, have been an area of great interest in the development of polymeric materials.Biodegradable polymers like poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and chitosan show a limited application due to their low mechanical properties. For this reason, the introduction of fillers for the reinforcement of materials, usually done in several engineering sectors, has been investigated to the development of materials for medical area. The cellulose nanocrystals (CNC) are among the fillers with great potential for medical applications, since they are not toxic, are obtained from natural source and show a high superficial area due their nanometric dimensions. This enables the improvement of some properties, using low concentrations of CNC. This way, this project intends to investigate the utilization of CNC as a reinforcement agent in the production of chitosan hydrogels and PHBV scaffolds, aiming medical applications. Nanocomposites with different concentrations of CNC will be produced and characterized by mechanical tests, swelling tests, differential scanning calorimetry (DSC), scanning electronic microscopy (SEM), and in vitro assays for cell adhesion/growth. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DO AMARAL MONTANHEIRO, THAIS LARISSA; MONTAGNA, LARISSA STIEVEN; PATRULEA, VIORICA; JORDAN, OLIVIER; BORCHARD, GERRIT; RIBAS, RENATA GUIMARAES; BASTOS CAMPOS, TIAGO MOREIRA; THIM, GILMAR PATROCINIO; LEMES, ANA PAULA. Enhanced water uptake of PHBV scaffolds with functionalized cellulose nanocrystals. Polymer Testing, v. 79, OCT 2019. (17/24873-4, 13/27064-9)

DO NASCIMENTO POMARI, ANDREIA APARECIDA; DO AMARAL MONTANHEIRO, THAIS LARISSA; DE SIQUEIRA, CRISTIANE PEREIRA; SILVA, RODRIGO SOUSA; TADA, DAYANE BATISTA; LEMES, ANA PAULA. Chitosan Hydrogels Crosslinked by Genipin and Reinforced with Cellulose Nanocrystals: Production and Characterization. JOURNAL OF COMPOSITES SCIENCE, v. 3, n. 3, p. 12-pg., 2019-09-01. (11/23895-8, 13/27064-9)

DA SILVA, ANA PAULA; DO AMARAL MONTANHEIRO, THAIS LARISSA; MONTAGNA, LARISSA STIEVEN; ANDRADE, PATRICIA FERNANDA; DURAN, NELSON; LEMES, ANA PAULA. Effect of carbon nanotubes on the biodegradability of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nanocomposites. Journal of Applied Polymer Science, v. 136, n. 40, OCT 20 2019. (13/27064-9)

AMARAL MONTANHEIRO, THAIS L.; MONTAGNA, LARISSA STIEVEN; BARROS MACHADO, JOAO PAULO; LEMES, ANA PAULA. Covalent functionalization of MWCNT with PHBV chains: Evaluation of the functionalization and production of nanocomposites. Polymer Composites, v. 40, n. 1, p. 288-295, JAN 2019. (13/27064-9)

DO AMARAL MONTANHEIRO, THAIS LARISSA; MONTAGNA, LARISSA STIEVEN; PATRULEA, VIORICA; JORDAN, OLIVIER; BORCHARD, GERRIT; MONTEIRO LOBATO, GABRIELA MATHEUS; CATALANI, LUIZ HENRIQUE; LEMES, ANA PAULA. Evaluation of cellulose nanocrystal addition on morphology, compression modulus and cytotoxicity of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) scaffolds. Journal of Materials Science, v. 54, n. 9, p. 7198-7210, MAY 2019. (13/27064-9, 11/21442-6)

TENORIO, FERNANDA SILVA; DO AMARAL MONTANHEIRO, THAIS LARISSA; ISAIAS DOS SANTOS, ALEXANDRE MARTINS; SILVA, MATEUS DOS SANTOS; LEMES, ANA PAULA; TADA, DAYANE BATISTA. Chitosan hydrogel covalently crosslinked by gold nanoparticle: Eliminating the use of toxic crosslinkers. Journal of Applied Polymer Science, v. 138, n. 6, AUG 2020. (17/01697-6, 17/24873-4, 13/27064-9)