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Use of canine freeze-dried cancellous bone graft associated to platelet-rich plasma or bone marrow in bone failures introduced in rabbits - experimental study

Grant number: 10/14072-5
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2011
Effective date (End): February 28, 2013
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal researcher:João Guilherme Padilha Filho
Grantee:Gláucia de Oliveira Morato
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil


Bone banks for grafting are very convenient to the surgeon for what concerns the treatment of huge bone losses and comminuted fractures. The use of cortical allografts conserved by several means is largely know, especially under conditions that demand mechanical support, and it is a low osteoconductivity graft, whereas the grafting with spongy bone is normally used in autogenous way, increasing the surgery time for material picking and post-surgery pain, besides incurring in insufficient amount of material for many times. It is a highly osteoconductive tissue and easy to be modeled for fitting into the receiver bed. However it is necessary studies that elucidate the effectiveness of spongy bone in bone repair after conservation in different means, thus making it possible the build of spongy bone banks. The platelet-rich plasma is a low cost source with easy acquisition of growing factors, including the ones involved in the bone growing. The bone marrow has multipotent cellularity with ability of renewing itself and differentiating in several tissue strains, being one of them the bone tissue. The objective of this study is to describe the bone repair when using allogeneic spongy bone conserved in glycerin at 98% as graft in bone failures introduced in rabbits and determine if the association of platelet-rich plasma or autogenous bone marrow to the treatment with spongy bone graft is beneficial to the consolidation process.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MORATO, Gláucia de Oliveira. Osso esponjoso liofilizado de cão utilizado como enxerto puro e associado a plasma rico em plaquetas ou medula óssea em falhas ósseas induzidas em coelhos: estudo experimental. 2013. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal Jaboticabal.

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