The role of prion protein in regulation of insulin signaling in normal conditions and in Alzheimer's Disease

• Grant number: 10/14254-6
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2011
• End date: November 30, 2012
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: Glaucia Noeli Maroso Hajj
• Grantee: Giovanna de Brito
• Host Institution: Hospital A C Camargo. Fundação Antonio Prudente (FAP). São Paulo , SP, Brazil

Abstract

The cellular prion protein, or PrPc, became known for being the normal cellular isoform of PrPSc, a protein involved in several neurodegenerative diseases. PrPc is a surface cell molecule that initiates signaling pathways and mediate physiological process, like protection against apoptosis, cell proliferation and adhesion. In this project we will study the relationship between insulin and PrPc. (AU)