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The role of prion protein in regulation of insulin signaling in normal conditions and in Alzheimer's Disease

Grant number: 10/14254-6
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2011
Effective date (End): November 30, 2012
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Principal researcher:Glaucia Noeli Maroso Hajj
Grantee:Giovanna de Brito
Home Institution: Hospital A C Camargo. Fundação Antonio Prudente (FAP). São Paulo , SP, Brazil

Abstract

The cellular prion protein, or PrPc, became known for being the normal cellular isoform of PrPSc, a protein involved in several neurodegenerative diseases. PrPc is a surface cell molecule that initiates signaling pathways and mediate physiological process, like protection against apoptosis, cell proliferation and adhesion. In this project we will study the relationship between insulin and PrPc. (AU)

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