Evaluation of the potential of nanostructured systems for incorporation of organic cocoa: study of the physico-chemical stability and antioxidant activity

• Grant number: 10/17723-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: March 01, 2011
• End date: February 29, 2012
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Marlus Chorilli
• Grantee: Erica Emi Funagoshi
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Lately several areas of science are coming together to understand, clarify, slow and reverse the aging process of the skin. This process should be studied because the changes in appearance can reveal inefficiencies that occur internally, and bring psychological consequences on the behavior of the person, both as to itself before the others. The use of natural organic materials in pharmaceutical and cosmetic formulations follows a market trend, given the huge boost the organic market has caused the economy. Among these materials, we highlight the use of organic cocoa that, because it is rich in polyphenols and condensed tannins, are believed to provide antioxidant potential. Associated with innovative nanostructured systems, such as liquid crystalline systems constituted by silicon film formers, the antioxidant activity of organic cocoa can thus be increased. This research aims to develop and characterize liquid crystalline systems increased organic cocoa, evaluate the physical and chemical stability and antioxidant activity of the formulations obtained. The structural characterization will be performed by analysis of polarized light microscopy, X-ray scattering Small Angle (SAXS) and rheological behavior and the stability study will be employed visual evaluation, pH and centrifugation. The antioxidant activity, in turn, will be determined based on the action of capturing the radical 1,1-diphenyl-2-picrylhydrazyl (DPPH).

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BRUNO FONSECA-SANTOS; ERICA EMI FUNAGOSHI; JOSÉ RICARDO SOARES DE OLIVEIRA; LUIS VITOR SILVA DO SACRAMENTO; ANDRÉ GONZAGA DOS SANTOS; GISLAINE RICCI LEONARDI; MARLUS CHORILLI. Organic cocoa extract -loaded surfactant-based systems intended to skin bioadhesion. Brazilian Journal of Pharmaceutical Sciences, v. 53, n. 3, 2017-10-26. (10/17723-7)

FONSECA-SANTOS, BRUNO; FUNAGOSHI, ERICA EMI; SOARES DE OLIVEIRA, JOSE RICARDO; SILVA DO SACRAMENTO, LUIS VITOR; DOS SANTOS, ANDRE GONZAGA; LEONARDI, GISLAINE RICCI; CHORILLI, MARLUS. Organic cocoa extract - loaded surfactant- based systems intended to skin bioadhesion. Brazilian Journal of Pharmaceutical Sciences, v. 53, n. 3, 2017. (10/17723-7)