In 2002, with the cloning of the (pro)renin receptor (PRR) was given a new vision to prorenin. When the prorenin binds to PRR exhibits catalytic activity and triggers intracellular signaling pathways, resulting finally in a role for the enzyme. These actions may contribute significantly to the development and progression of target organ damage in diabetes and hypertension. Recently, a transgenic mouse expressing rat tonin, called TGM (rton), was generated by the group of Prof. Dr. Jorge L. Pesquero and has been extensively studied. Initial data showed that this animal has cardioprotective and resistance to the process of hypertrophy induced by isoproterenol, giving this enzyme a possible cardioprotective role. In addition to this function, we suggest that the environment in excess of tonin can activate cellular signaling processes or alter gene expression of different peptides/enzymes, such as modulation of isoform N-domain of ACE, probably by activating the synthesis of a secretase. For the first time it was shown the physiological action of tonin as an important modulator of cardiac renin-angiotensin system, particularly in the atria. So, we decided to verify the modulation of PRR in transgenic mice expressing tonin enzyme of the alternative pathway in the release of angiotensin II (Ang II), subjected to acute myocardial infarction.
News published in Agência FAPESP Newsletter about the scholarship: