(Pro)renin receptor expression in myocardial infarction in transgenic mice expressing rat tonin

Author(s)

Ribeiro, Amanda A. ^[1] ; Amorim, Rebeca Padrao ^[2] ; Palomino, Zaira J. ^[1] ; Lima, Mercia de Paula ^[3] ; Moraes-Silva, Ivana Cinthya ^[4] ; Souza, Leandro Ezequiel ^[4] ; Pesquero, Jorge Luiz ^[3] ; Irigoyen, Maria Claudia ^[4] ; Casarini, Dulce E. ^[1]

Affiliation

^[1] Univ Fed Sao Paulo, Escola Paulista Med, Dept Med, Nephrol Div, Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo, Escola Paulista Med, Dept Neurol & Neurosurg, Expt Neurol Div, Sao Paulo, SP - Brazil

^[3] Univ Fed Minas Gerais, Dept Biophis, Belo Horizonte, MG - Brazil

^[4] Univ Sao Paulo, Heart Inst, Dept Hpertens, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: International Journal of Biological Macromolecules; v. 108, p. 817-825, MAR 2018.
• Web of Science Citations: 5

Abstract

The (pro)renin receptor {[}(P)RR] has been implicated as a renin/prorenin receptor, and plays a role in local renin angiotensin system activation. Our goal was to investigate whether a transgenic mouse that expresses rat tonin {[}TGM'(rTon)] can regulate (P)RR mRNA levels. Control (C) and TGM'(rTon) animals were subdivided into the C sham, C MI, TGM'(rTon) sham, and TGM'(rTon) MI groups. The levels of tonin, (P)RR, and renin were determined using RT-PCR mRNA. Tonin activity as determined by RIE was significantly increased in the TGM'(rTon) sham group as compared to the C sham group in the atrium (AT) and right ventricle (RV), respectively. In most mice, tonin mRNA levels were significantly reduced compared to those in the TGM'(rTon) sham group in the atria. In this structure, the (P)RR mRNA levels were statistically significantly reduced in the TGM'(rTon) sham and TGM'(rTon) MI groups compared to the control groups. However, the (P)RR mRNA values were significantly increased when we compared the TGM'(rTon) MI vs TGM'(rTon) sham groups. In the RV, the renin mRNA levels in the TGM'(rTon) sham group were significantly reduced compared to the C sham group. Tonin overexpression may act in the regulation of (P)RR mRNA levels during MI. (C) 2017 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 10/19989-4 - The role of renin pro-receptor in acute myocardial infarction in transgenic mouse express tonin rat.
• Grantee: Amanda Aparecida Ribeiro
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 10/51904-9 - Renin angiotensin and kallikrein kinin systems in hypertension, obesity, diabetes, desnutrition and sepsis: molecular, cellular and physiopathologic mechanisms
• Grantee: Dulce Elena Casarini
• Support Opportunities: Research Projects - Thematic Grants