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Effects of dexmedetomidine on renal function in ischemia and reperfusion model in rats

Grant number: 10/16431-2
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): March 01, 2011
Effective date (End): February 29, 2012
Field of knowledge:Health Sciences - Medicine - Surgery
Principal researcher:Norma Sueli Pinheiro Módolo
Grantee:Marcela Tsubouchi Ferreira
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

BACKGROUND AND PURPOSE: Hemodynamic changes lead to perioperative renal hypoperfusion with consequent failure of the organ. Ischemia and reperfusion lesion is the primary cause of acute renal failure in this period, increasing the morbidity and mortality. Dexmedetomidine is a selective ±2 agonist that improves hemodynamic stability during surgery. Its effect on renal function was studied in cases of hemorrhage. This research objective is to study the effects of dexmedetomidine on renal function in a model of ischemia and reperfusion in rats. METHODS: Thirty adult rats will be randomized into three groups: Group S or Sham (n = 10) anesthetized with isoflurane and dexmedetomidine (3mcg/Kg in 10 minutes, followed by 3mcg/Kg/h) and submitted to laparotomy with right nephrectomy; Group C or control (n = 10) anesthetized with isoflurane and submitted to laparotomy and right nephrectomy with left renal artery clamping for 30 minutes followed by reperfusion for 30 minutes; Study Group E (n = 10) anesthetized with isoflurano and dexmedetomidine (3mcg/Kg in 10 minutes, followed by 3mcg/Kg/h) laparotomy and right nephrectomy with left renal artery clamping for 30 minutes followed reperfusion for 30 minutes. Hemodynamic variables (heart rate and blood pressure), temperature and biochemical markers of renal function (NGAL, creatinine and interleukins) will be studied immediately after stabilization (M1), thirty minutes after left renal artery clamping (M2), thirty minutes after renal reperfusion (M3) and 24 hours after reperfusion (M4). KEY WORDS: Dexmedetomidine, kidney, renal protection, Ischemia and reperfusion.

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