Acute effects of sidestream cigarette smoke and particulate matter exposure on autonomic modulation of cardiovascular system

• Grant number: 10/17769-7
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: August 01, 2011
• End date: November 30, 2011
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Paulo Hilário Nascimento Saldiva
• Grantee: Vitor Engrácia Valenti
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The cardiovascular system is modulated by group of neurons located in the medulla oblongata, which include the nucleus of the solitary tract (NTS) and rostroventrolateral medulla (RVL). It has been shown the link between pollution and increased cardiovascular morbidity and mortality, as fine particles reach the alveolar-capillary territory and get into the bloodstream in less than one minute. The sidestream cigarette smoke comes from the spontaneous combustion of the cigarette and become part of about 85% of the total smoke released by the cigarette smoke, hence, is an important pollutant agent to investigate. Acute hemodynamic and sympathetic responses to smoking have been previously demonstrated in association with mainstream and sidestream cigarette smoke in humans, suggesting that the baroreflex function in active smokers is compromised. Furthermore, results from our group showed the involvement of catalase inhibition into the fourth cerebral ventricle (4th V) on the influence of the parasympathetic response due to increased blood pressure in Wistar Kyoto and spontaneously hypertensive rats exposed to sidestream cigarette smoke for three weeks. However, it is not yet confirmed the effects of catalase inhibition on central and systemic control of the baroreflex and cardiopulmonary reflex in rats acutely exposed to cigarette smoke and particulate matter. Thus, we aim to to evaluate the effects of central and systemic catalase inhibition on baroreflex and cardiopulmonary reflex in rats acutely exposed to sidestream cigarette smoke and particulate matter.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VITOR E. VALENTI; LUIZ CARLOS DE ABREU; FERNANDO L. A. FONSECA; FERNANDO ADAMI; MONICA A. SATO; LUIZ CARLOS M. VANDERLEI; LUCAS LIMA FERREIRA; LUCIANO M. RODRIGUES; CELSO FERREIRA. Effects of the administration of a catalase inhibitor into the fourth cerebral ventricle on cardiovascular responses in spontaneously hypertensive rats exposed to sidestream cigarette smoke. Clinics, v. 68, n. 6, p. 851-857, 2013-06-00. (10/17769-7)