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Grant number: 10/19026-1
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): April 01, 2011
Effective date (End): February 29, 2012
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Marco Túlio de Mello
Grantee:Fábio Santos de Lira
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


It is now known that sleep is extremely important, and changes in sleep architecture are associated with several diseases such as obesity, diabetes, hypertension, etc.. Situations such as high altitude (hypoxia) has been described as potent detrimental to the sleep architecture. Such changes are caused mainly by hormonal changes, such as catecholamines, cortisol, and also of pro-inflammatory cytokines. Moreover, the effects of exercise on sleep patterns in conditions of high altitude are poorly understood. Isolated studies suggest that hypoxia may cause the effects of exercise on the concentration of cytokines and the pattern of sleep may be exacerbated in a manner dependent on the altitude, ie the intensity of hypoxia in which people may be exercising. However, the altitude at which the effects of exercise on sleep patterns become more evident are still unknown. Therefore, this study aims to evaluate the role of cytokines on the regulation of sleep after acute exercise at different altitudes. Our hypothesis is exercise performed at high altitude changes the concentration of several cytokines and may thus exert deleterious effects on sleep patterns.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LEMOS, VALDIR DE AQUINO; THOMATIELI DOS SANTOS, RONALDO VAGNER; MOREIRA ANTUNES, HANNA KAREN; BEHN, CLAUS; VISCOR, GINES; LIRA, FABIO SANTOS; LUZ BITTAR, IRENE GUARIDO; CARIS, ALINE VENTICINQUE; TUFIK, SERGIO; DE MELLO, MARCO TULIO. Melatonin and sleep responses to normobaric hypoxia and aerobic physical exercise: A randomized controlled trial. Physiology & Behavior, v. 196, p. 95-103, NOV 1 2018. Web of Science Citations: 0.
LIRA, FABIO S.; LEMOS, VALDIR A.; BITTAR, IRENE G. L.; CARIS, ALINE V.; DOS SANTOS, RONALDO V. T.; TUFIK, SERGIO; ZAGATTO, ALESSANDRO M.; DE SOUZA, CLAUDIO T.; PIMENTEL, GUSTAVO D.; DE MELO, MARCO T. Physiological and cytokine response to acute exercise under hypoxic conditions: a pilot study. JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS, v. 57, n. 4, p. 461-468, APR 2017. Web of Science Citations: 1.

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