Incidence of vertebral fractures and non-vertebral clinical fractures in a population of individuals age 65 or more

• Grant number: 11/00411-5
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: April 01, 2011
• End date: December 31, 2011
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Rosa Maria Rodrigues Pereira
• Grantee: Diogo Souza Domiciano
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Osteoporosis, although a global problem of public health, in part due to the increase in the number of people aged more than 65 years, is still largely neglected in developing countries. Besides the Bone Mineral Density (BMD) obtained by densitometry, several clinical factors are identified as associated with increased risk of this disease. Aiming to better predict the risk of fractures in men and women, John Kanis recently started a project to develop a tool for tracking the risk of fracture (FRAX). FRAXTM was developed with support from the World Health Organization, with the participation of other institutions such as the International Osteoporosis Foundation, National Osteoporosis Foundation, International Society for Clinical densitometry and American Society for Bone and Mineral Research. The purpose of this tool is to identify individuals with low BMD (T-score between -1 and -2.5) have high risk of fracture, and therefore would benefit from treatment for osteoporosis. This instrument has been widely used in the world helping the physician in his decision to treat or not the patient at risk for fracture. For correct application of FRAX, each country should meet its epidemiology for fractures related to osteoporosis and its outcomes, and mortality rates. Accordingly, from the original work of Kanis et al. in the United Kingdom FRAX has been adapted for several other countries, but not in Brazilian population. This project aims to conduct a study of the incidence of vertebral fractures, no clinical vertebral fractures and mortality in a sample of elderly of our population, whose prevalence of fractures and osteoporosis was previously studied (FAPESP # 03/09313-0). In addition, to analyze the risk factors for fractures (age, age at menopause, smoking, alcohol, physical activity, calcium intake, family history of OP, glucocorticoids, falls, etc) in these individuals and from these data we will validate a version the FRAX (WHO Fracture Risk Assessment Tool) for the Brazilian population. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PEREIRA, ROSA MARIA R.; FREITAS, THIAGO QUADRANTE; FRANCO, ANDRE SILVA; TAKAYAMA, LILIAM; CAPARBO, VALERIA F.; DOMICIANO, DIOGO S.; MACHADO, LUANA G.; FIGUEIREDO, CAMILLE P.; MENEZES, PAULO R.; ONUCHIC, LUIZ FERNANDO; et al. KLOTHO polymorphisms and age-related outcomes in community-dwelling older subjects: The SAo Paulo Ageing & Health (SPAH) Study. SCIENTIFIC REPORTS, v. 10, n. 1, MAY 22 2020. (11/00411-5, 03/09313-0, 09/15346-4, 04/12694-8)

DOMICIANO, DIOGO S.; MACHADO, LUANA G.; LOPES, JAQUELINE B.; FIGUEIREDO, CAMILLE P.; CAPARBO, VALERIA F.; OLIVEIRA, RICARDO M.; SCAZUFCA, MARCIA; MCCLUNG, MICHAEL R.; PEREIRA, ROSA M. R.. Bone Mineral Density and Parathyroid Hormone as Independent Risk Factors for Mortality in Community-Dwelling Older Adults: A Population-Based Prospective Cohort Study in Brazil. The SAo Paulo Ageing & Health (SPAH) Study. Journal of Bone and Mineral Research, v. 31, n. 6, p. 1146-1157, JUN 2016. (09/15346-4, 03/09313-0, 04/12694-8, 11/00411-5)

DE SANTANA, FELIPE M.; DOMICIANO, DIOGO S.; GONCALVES, MICHEL A.; MACHADO, LUANA G.; FIGUEIREDO, CAMILLE P.; LOPES, JAQUELINE B.; CAPARBO, VALERIA F.; TAKAYAMA, LILLIAM; MENEZES, PAULO R.; PEREIRA, ROSA M. R.. Association of Appendicular Lean Mass, and Subcutaneous and Visceral Adipose Tissue With Mortality in Older Brazilians: The Sao Paulo Ageing & Health Study. Journal of Bone and Mineral Research, v. 34, n. 7, p. 1264-1274, JUL 2019. (09/15346-4, 03/09313-0, 04/12694-8, 11/00411-5)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

DOMICIANO, Diogo Souza. Vertebral fractures, Incidence and risk factors for osteoporotic vertebral fracture in low-income community-dwelling elderly: a population-based prospective cohort study in Brazil. 2015. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.