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Tissue engineering through simulation of spheroids as structuring blocks on biofabrication

Grant number: 10/20763-0
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): April 01, 2011
Effective date (End): March 31, 2014
Field of knowledge:Engineering - Chemical Engineering
Principal Investigator:Jorge Vicente Lopes da Silva
Grantee:Rodrigo Alvarenga Rezende
Home Institution: Centro de Pesquisas Renato Archer (CENPRA). Ministério da Ciência, Tecnologia, Inovações e Comunicações (Brasil). Campinas , SP, Brazil


Recovering damaged organs and tissues is the main challenge on Tissue Engineering. However, the risk of rejection by organism and the dependence on immunosupressors can be reasons to the limited successful of this process. So, the purpose of fabricate organs known as bioprinting has been studied in the last years. This technique not depends on the implantation of support structures to the new tissue formation, which is closer to the natural, and is based on the organs and macrotissues construction layer by layer by means of spheroids that work as base-block of structuring. This project aims to study the physical and biological conditions suitable to the use of spheroids on Biofabrication, as structuring blocks, through computational simulations. In a same way, the internal environment of bioreactors will be simulated which are employed in order to accelerate the maturing process of the tissue by the control of their mechanical, biochemical and electrical conditions, and for tests and monitoring of these processes on the fabrication of the designed tissues. In addition, this Post-Doctorate project will be linked to the Thematic Project on Biofabrication (INCT BIOFABRIS n.08/57860-3 FAPESP e n.573661/2008-1 CNPQ). (AU)