Comparative study of three different meshes (polypropylene, polyglecaprone and polyglecaprone covered by polyglecaprone film) in the repair of incisional hernia in rats

• Grant number: 11/06111-3
• Support type: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): May 01, 2011
• Effective date (End): December 31, 2011
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Edivaldo Massazo Utiyama
• Grantee: Maria Beatriz Sartor de Faria
• Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Incisional hernia is the most common complication of abdominal surgery. Despite 100000 ventral hernia repair are performed annually, there is no consensus about which mesh is better. The objective of this study is to use an experimental animal model of incisional hernia to compare biomechanical, inflammatory and cicatricial response of three different meshes on the abdominal hernia repair.Methods: 40 Wistar rats will be submitted to median fascial incision and only skin synthesis. After 21 days, the abdominal hernia developed will be corrected according to four groups: Sham (suture of abdominal wall), Group 1 (suture of abdominal wall and placement of a polypropylene mesh), Group 2 (suture of abdominal wall and placement of polypropylene/polyglecaprone mesh) and Group 3 (suture of abdominal wall and placement of a polypropylene/polyglecaprone mesh covered with a polyglecaprone film). After 21 days the mesh and surrounding tissue will be submitted to macroscopic (presence of adhesions, mesh retraction) and microscopic analysis (inflammatory, cicatricial response). (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

EDIVALDO MASSAZO UTIYAMA; MARIA BEATRIZ SARTOR DE FARIA ROSA; MARINA DE PAULA ANDRES; JOCIELLE SANTOS DE MIRANDA; SÉRGIO HENRIQUE BASTOS DAMOUS; CLÁUDIO AUGUSTO VIANNA BIROLINI; LUCIANA LAMARÃO DAMOUS; EDNA FRASSON DE SOUZA MONTERO. Polypropylene and polypropylene/polyglecaprone (Ultrapro(r)) meshes in the repair of incisional hernia in rats. Acta Cirurgica Brasileira, v. 30, n. 6, p. -, Jun. 2015.

UTIYAMA, EDIVALDO MASSAZO; SARTOR DE FARIA ROSA, MARIA BEATRIZ; ANDRES, MARINA DE PAULA; DE MIRANDA, JOCIELLE SANTOS; BASTOS DAMOUS, SERGIO HENRIQUE; VIANNA BIROLINI, CLAUDIO AUGUSTO; DAMOUS, LUCIANA LAMARAO; DE SOUZA MONTERO, EDNA FRASSON. Polypropylene and polypropylene/polyglecaprone (Ultrapro (R)) meshes in the repair of incisional hernia in rats. Acta Cirurgica Brasileira, v. 30, n. 6, p. 376-381, JUN 2015. Web of Science Citations: 5.