Prospective analysis of the blood serum metabolome of patients undergoing bone marrow transplantation in the study of the GVHD (Graft-Versus-Host Disease)

• Grant number: 11/06441-3
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: August 01, 2011
• End date: July 31, 2015
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Ana Carolina de Mattos Zeri
• Grantee: Marcos Rodrigo Alborghetti
• Host Institution: Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Ministério da Ciência, Tecnologia e Inovação (Brasil). Campinas , SP, Brazil
• Associated scholarship(s): 13/06729-2 - Metabolomic study of the biochemical mechanism of action of 2-aminoadipate in type 2 diabetes mellitus development, BE.EP.PD

Abstract

The Metabolomics, or quantitative analysis of metabolites produced by an organism under certain conditions, is according to the philosophy of systems biology because it provides an integrated view of biochemistry in complex organisms, as opposed to the traditional approach that investigates the network of interactions between genes, proteins and metabolites in individual cell types. Along with the overall result of all factors that influence a particular disease or trait, we can reach conclusions that exclude a single cause for the result. Thus, metabolomics is essential for systems biology, which emphasizes a holistic approach to biology, rather than reductionist. This approach is essential to define a personalized medicine through the establishment of profiles of metabolites biomarkers for certain disease states. The identification of biomarkers that can potentially lead to the creation of simplified tests, is of vital importance for both clinicians and patients in the early diagnosis and prognosis and monitoring of therapy and may lead to increased survival and cure rates. The purpose of this project is based on this perspective, using quantitative analysis of metabolites by nuclear magnetic resonance (NMR), and aims to study the graft-versus-host disease (GVHD). GVHD is an autoimmune-like disease which affects about 50% of patients with allogeneic bone marrow transplantation. It is responsible for high morbidity and mortality due to severe tissue destruction. The therapy is based on immunosuppression of the patient. By analyzing blood serum of patients by NMR-based Metabolomics aims to raise a profile of candidate biomarkers with potential to predict disease development, even before transplantation, diagnosis or monitoring of therapy.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ALBORGHETTI, MARCOS RODRIGO; PIZZIGATTI CORREA, MARIA ELVIRA; WHANGBO, JENNIFER; SHI, XU; ARICETTI, JULIANA APARECIDA; DA SILVA, ANDREIA APARECIDA; MARTINS MIRANDA, ELIANA CRISTINA; SFORCA, MAURICIO LUIS; CALDANA, CAMILA; GERSZTEN, ROBERT E.; et al. Clinical Metabolomics Identifies Blood Serum Branched Chain Amino Acids as Potential Predictive Biomarkers for Chronic Graft vs. Host Disease. FRONTIERS IN ONCOLOGY, v. 9, MAR 18 2019. (11/06441-3)