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Polymorphisms of BMP-4 gene and its relationship with hirsutism in women with polycystic ovary syndrome

Grant number: 10/20668-8
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2011
Effective date (End): July 31, 2012
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Gustavo Arantes Rosa Maciel
Grantee:Vera Bain
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Polycystic Ovary Syndrome is a complex endocrine disease characterized by hyperandrogenism and anovulation. Hirsutism, which is, the excessive facial and body hair caused by excessive androgen action in women, is one of the most prevalent signs of hyperandrogenism. It is a clinical problem of great importance but its pathophysiology is largely elusive. Bone Morphogenetic Proteins belong to the TGF Beta superfamily and is known to modulate a wide series of biological processes such as development and reprocution. Recently,BMP family, especially BMP-4 and BMP-2, has been implicated in the physiology of the hair, and are thought to coordenate the growth phase. In this project, we proposed to evaluate the epidemiology of hirsutism at the Division of Hyperandrogenism of the Discipline of Gynecology, to study two polymosphism of BMP-4 gene of PCOS subjects and to compared the data with women without the syndrome.