| Grant number: | 11/04283-1 |
| Support Opportunities: | Scholarships in Brazil - Master |
| Start date: | August 01, 2011 |
| End date: | February 28, 2013 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry - Organic Chemistry |
| Principal Investigator: | Daniel Rodrigues Cardoso |
| Grantee: | Andressa de Zawadzki |
| Host Institution: | Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil |
Abstract For long time the anions nitrate (NO3-) and nitrite (NO2-) were considered inert end products of nitric oxide (NO) metabolism and undesirable constituents of the diet. However, there is a increasing interest for potential reactions which may occur in physiological condictions involving specially the nitrite ion and mediated by transition metal complexes. Heme iron present in proteins, such as myoglobin, may form porphyrin complexes with NO yielding species that may act as catalysts in several important biologic pathways. Complexes with NOx coordinated to heme iron are involved in meat curing process (meat pigmentation) and in redox processes as well, are able to oxidize substrates indirectly generating reactive species or directly by oxygen-atom transfer reactions. Lipids, fundamental cellular constituents of membranes and lipoproteins, may serve as substrates to those reactions and their oxidation may promote damage to the organism. Considering that the mechanism and kinetic and thermodinamic parameters of these reaction have not yet been fully elucidated to explain the varied functionality of these complexes, the present research project aim to bring a better understanding of redox reactions involving NOx mediated by iron porphyrins in foods and biological systems. (AU) | |
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