Evaluation of hypoglycemic effect of the extract of Bauhinia holophylla in diabetic mice induced by streptozotocin

• Grant number: 10/12901-4
• Support Opportunities: Scholarships in Brazil - Master
• Start date: August 01, 2011
• End date: July 31, 2013
• Field of knowledge: Biological Sciences - Pharmacology - Ethnopharmacology
• Principal Investigator: José Roberto Bosqueiro
• Grantee: Nathalia Aparecida de Paula Camaforte Henriques
• Host Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil
• Associated research grant: 09/52237-9 - Standardized herbal medicines for the treatment of chronic diseases, AP.BTA.TEM

Abstract

The concern with health has been growing up a lot in the past years due to large increase of the called chronic non-communicable diseases, among them obesity, arterial hypertension,dislipidemia, diabetes mellitus (DM) and cardiovascular diseases. Diabetes Mellitus is one of the more important causes of death in occidental countries. Around the world there are 177 million diabetic people and this number should double by 2030. Some plants used in the popular medicine are associated to the treatment of diabetes because of they therapeutic potential, but some are considered highly toxic and can produce hipoglycemia as side effect. The genus Bauhinia belongs to the family Fabaceae, being native of the Cerrado and according some studies their hypoglycemic action is due to the presence of flavonoids in its composition. There are several species widely used in the popular medicine as hypoglycemiants, however studies about possibles hypoglycemic actions of some species, like B. holophylla for example still are not found. Thus, the proposal of this project is to evaluate the therapeutic effects of B. holophylla in diabect mice induced by streptozotocin. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

HENRIQUES, Nathalia Aparecida de Paula Camaforte. Avaliação da atividade hipoglicemiante do extrato bruto de Bauhinia holophylla (Steud.) em camundongos diabéticos induzidos por estreptozotocina. 2013. Master's Dissertation - Universidade Estadual Paulista (Unesp). Instituto de Biociências. Botucatu Botucatu.