Molecular characterization of dengue virus isolated in Ribeirão Preto from 2009 to 2012

• Grant number: 11/04299-5
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2012
• End date: February 28, 2014
• Field of knowledge: Biological Sciences - Microbiology - Applied Microbiology
• Principal Investigator: Victor Hugo Aquino Quintana
• Grantee: Adriana Moreira Soares
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Dengue is an infectious disease of high morbidity and mortality that affects a large number of individuals in tropical and subtropical countries of the world. Infection with any of the four serotypes of dengue virus (DENV-1, -2, -3 and -4) may be asymptomatic or lead to clinical conditions ranging from an unknown and self-limiting fever, through classic dengue fever (DF) and severe called dengue hemorrhagic fever/dengue shock syndrome (DHF / DSS). Several methods are used to diagnose dengue, as molecular methods, serological methods and the detection of the viral NS1 protein. Currently, there are circulating around the country the DENV-1, -2 and -3; while DENV-4 was detected only in the North Region. In Ribeirao Preto, the first epidemic occurred between November 1990 and March 1991, caused by DENV-1 with 2305 confirmed cases. The largest epidemic of the city occurred in 2010, when 29,959 cases and nine deaths were reported, with a higher prevalence of DENV-1, but DENV-2 and -3 were also detected. Between January and February 2011, 2,252 cases and one death have been reported, with the circulation of DENV-1, -2 and -3. In this work, we aim to characterize molecularly the viruses isolated in Ribeirão Preto from 2009 to 2012 and to perform phylogenetic and evolutionary analysis of them. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SOARES, Adriana Moreira. Molecular characterization of dengue vírus isolated in Ribeirão Preto in 2010 and 2011. 2014. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.