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ARHGAP21 INHIBTS INSULIN SECRETION AND CONTROLS GLUCOSE HOMEOSTASE IN MICE

Grant number: 11/12050-7
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): October 01, 2011
Effective date (End): January 31, 2015
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Antonio Carlos Boschiero
Grantee:Sandra Mara Ferreira
Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

ARHGAP21 is a Rho-GAP that, like Cdc42 and FAK, modulates the activity of proteins involved with rearrangement of actin cytoskeleton in pancreatic beta cell, leading the inhibition of insulin secretion. Furthermore, glucose modulates the ARHGAP21/FAK and ARHGAP21/Cdc42 interactions, which may explain, at least in part, the control of insulin secretion by ARHGAP21. However, the pathways by which glucose control ARHGAP21 remain unknowns. In addition, despite of ARHGAP21 is related with protein involved with rearrangement of actin cytoskeleton, and, therefore, extrusion of insulin granule, still not known the role of ARHGAP21 on secretory machinery and release of insulin granule. Therefore, the aim of study is assessed in MIN6 cells and isolated islets of mice, the possible pathways of glucose signalization modulate the ARHGAP21 activity and the possible control of secretory machinery and insulin release in that Rho-GAP.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERREIRA, SANDRA M.; COSTA-JUNIOR, JOSE M.; KURAUTI, MIRIAN A.; LEITE, NAYARA C.; ORTIS, FERNANDA; REZENDE, LUIZ F.; BARBOSA, HELENA C.; BOSCHERO, ANTONIO C.; SANTOS, GUSTAVO J.. ARHGAP21 Acts as an Inhibitor of the Glucose-Stimulated Insulin Secretion Process. FRONTIERS IN ENDOCRINOLOGY, v. 11, . (11/12050-7, 11/09012-6)
FERREIRA, SANDRA MARA; SANTOS, GUSTAVO JORGE; REZENDE, LUIZ F.; GONCALVES, LUCIANA MATEUS; SANTOS-SILVA, JUNIA CAROLINA; BIGARELLA, CAROLINA LOUZAO; CARNEIRO, EVERARDO MAGALHAES; OLLALA SAAD, SARA TERESINHA; BOSCHERO, ANTONIO CARLOS; BARBOSA-SAMPAIO, HELENA CRISTINA. ARHGAP21 prevents abnormal insulin release through actin rearrangement in pancreatic islets from neonatal mice. Life Sciences, v. 127, p. 53-58, . (08/57952-5, 11/12050-7)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FERREIRA, Sandra Mara. ARHGAP21 inhibits insulin secretion and controls glucose homeostase in mice. 2015. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia.

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