Correlations between cytokines, depression and anxiety in patients with colorectal cancer in adjuvant and palliative chemotherapy.

• Grant number: 11/17118-9
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): December 01, 2011
• Effective date (End): November 30, 2014
• Field of knowledge: Health Sciences - Nursing - Medical-Surgical Nursing
• Principal Investigator: Gabriela Silva Bisson
• Grantee: Diego Oliveira Miranda
• Host Institution: Escola de Enfermagem de Ribeirão Preto (EERP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Colorectal cancer (CRC) is a leading cause of cancer mortality in the world. Depression and anxiety are the most prevalent psychological disorders in patients with CRC. The occurrence of these symptoms impairs the adherence to cancer treatment, the quality of life of patients and increases the burden of health services. Proper management of these disorders is therefore an important issue in oncology nursing practice. Evidences suggesting a role of cytokines in the pathophysiology of depression, combined with the presence of high levels of these molecules in cancer patients suggest that they can play an important role in the etiology and phenomenology of depression and anxiety in these subjects. A holistic understanding of these factors will allow the design of nursing interventions that lead to an improved quality of life and overall survival of patients with CRC. This study aims to investigate whether there is a correlation between anxiety, depression and serum cytokines in patients with colorectal cancer at different times of adjuvant or palliative chemotherapy. To this end, adult patients who underwent surgical resection and are initiating an adjuvant or palliative chemotherapy with capecitabine and oxaliplatin at the Department of Clinical Oncology of HCFMRP/USP will be invited to participate in the study.. Depression and anxiety will be analyzed using the HADS scale (Hospital Anxiety and Depression Scale) and serum levels of IL-1, IL-6, INF-gamma, TNF-alpha, TGF-beta, IL-10 and fractalkine (CX3C) will be measured by ELISA. Comparison between the sample groups will be conducted by ANOVA-F and Kruskal-Wallis test and p values < 0.05 will be considered statistically significant.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MIRANDA, DIEGO OLIVEIRA; SOARES DE LIMA, TAIS APARECIDA; AZEVEDO, LUCAS RIBEIRO; FERES, OMAR; RIBEIRO DA ROCHA, JOSE JOAQUIM; PEREIRA-DA-SILVA, GABRIELA. Proinflammatory Cytokines Correlate with Depression and Anxiety in Colorectal Cancer Patients. BIOMED RESEARCH INTERNATIONAL, 2014. (13/01262-9, 11/17118-9)

MIRANDA, DIEGO OLIVEIRA; ANATRIELLO, ELEN; AZEVEDO, LUCAS RIBEIRO; SANTOS, JESSICA CRISTINA; CORREA CORDEIRO, JESSICA FERNANDA; PERIA, FERNANDA MARIS; FLORIA-SANTOS, MILENA; PEREIRA-DA-SILVA, GABRIELA. Fractalkine (C-X3-C motif chemokine ligand 1) as a potential biomarker for depression and anxiety in colorectal cancer patients. BIOMEDICAL REPORTS, v. 7, n. 2, p. 188-192, AUG 2017. (13/01262-9, 11/17118-9)

MIRANDA, DIEGO O.; ANATRIELLO, ELEN; AZEVEDO, LUCAS R.; CORDEIRO, JESSICA F. C.; PERIA, FERNANDA M.; FLORIA-SANTOS, MILENA; PEREIRA-DA-SILVA, GABRIELA. Elevated serum levels of proinflammatory cytokines potentially correlate with depression and anxiety in colorectal cancer patients in different stages of the antitumor therapy. CYTOKINE, v. 104, p. 72-77, APR 2018. (13/01262-9, 11/17118-9)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MIRANDA, Diego Oliveira. Correlation between cytokines, depression, and anxiety in colorectal cancer patients in different stages of the antitumor therapy. 2014. Doctoral Thesis - Universidade de São Paulo (USP). Escola de Enfermagem de Ribeirão Preto (PCARP/BC) Ribeirão Preto.