HYBRID MATERIALS CONTAINING Mn OR Co-DOPED ZnO NANOPARTICLES FOR CONTROLLED DRUG RELEASE

• Grant number: 11/19253-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Effective date (Start): December 01, 2011
• Effective date (End): November 30, 2015
• Field of knowledge: Engineering - Materials and Metallurgical Engineering
• Principal Investigator: Celso Valentim Santilli
• Grantee: Bruno Leonardo Caetano
• Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated scholarship(s): 13/10384-0 - Hybrid materials containing Mn or Co-doped ZnO nanoparticles for controlled drug release: magnetic characterization and applications of the systems as a source of hyperthermia, BE.EP.PD

Abstract

This project consists on the preparation and characterization of controlled drug release devices using polyether-siloxane hybrids matrices containing Mn or Co-doped ZnO nanoparticles. Polyether-siloxane hybrids matrices show single properties as high mechanical resistance, transparency and flexibility being a potential material for several scientific and technological areas including the use in drug delivery devices. ZnO semiconductor nanoparticles has strongly attracted attention of the researchers due to their electronic, luminescent, catalytic and optoelectronics varying significantly with particle sized. Other relevant factor is the possibility of the doped ZnO nanoparticles with magnetic elements creating new class of materials known as diluted magnetic semiconductors (DMS), a multifunctional material with magneto-optical properties. The proposal of this work aims prepare a controlled drug release device combining the individual properties of each component in the same material, using the magnetic property of the DMS to drive the delivery device on the sick organ and the luminescent property of the ZnO to monitor the device position inside the human body.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CAETANO, B. L.; GUIBERT, C.; FINI, R.; FRESNAIS, J.; PULCINELLI, S. H.; MENAGER, C.; SANTILLI, C. V.. Magnetic hyperthermia-induced drug release from ureasil-PEO-gamma-Fe2O3 nanocomposites. RSC ADVANCES, v. 6, n. 68, p. 63291-63295, 2016. (13/10384-0, 11/19253-0)