The role of PrPc-HOP complex in colon tumors

• Grant number: 11/18718-0
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: December 01, 2011
• End date: November 30, 2015
• Field of knowledge: Biological Sciences - Biochemistry
• Principal Investigator: Vilma Regina Martins
• Grantee: Tonielli Cristina Sousa de Lacerda
• Host Institution: A C Camargo Cancer Center. Fundação Antonio Prudente (FAP). São Paulo , SP, Brazil
• Associated research grant: 09/14027-2 - Mechanisms associated with the function of prion protein and its ligand STI1/Hop: therapeutic approaches, AP.TEM

Abstract

Colorectal cancer is the fourth most common cancer in the world, with a high rate of mortality and morbidity. The understanding of the mechanisms underlying this disease is of considerable impact. The cellular prion protein (PrPC), well-known for its functions in the nervous system, is among the molecules with a potential role in these tumors. The activity of PrPC depends on its interaction with other proteins including the stress inducible Protein1 (STI1), or its human homologue named Hsp90/Hsp70 organizing protein (HOP). Both PrPC and STI1/HOP are linked to cell proliferation and metastasis in tumors. The signaling pathways triggered by PrPC-STI1/Hop complex depend on the STI1/HOP secretion into the extracellular space, however the mechanisms used for STI1/Hop secretion are unknown. The present proposal aims to investigate the mechanisms associated to the secretion of HOP and to understand the participation of the PrPC-HOP complex in the tumorigenic processes using in vitro and in vivo models. In addition, the significance of HOP as a biomarker in serum of patients with colorectal tumors will also be addressed. The proposed experiments should provide a new insight into the use of PrPC-Hop complex as a therapeutic target in colon cancer. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BAPTISTEILA, ANTUANI RAFAEL; LANDEMBERGER, MICHELE CHRISTINE; SALLES DIA, MARCOS VINICIOS; GIUDIC, FERNANDA SALGUEIREDO; RODRIGUES, BRUNA ROZ; COMBAS EUFRAZIO DA SILV, PETRUS PAULO; CASSINELA, EDSON KUATELELA; LACERDA, TONIELLI CRISTINA; MARCHI, FABIO ALBUQUERQUE; PAES LEME, ADRIANA FRANCO; et al. Rab5C enhances resistance to ionizing radiation in rectal cancer. JOURNAL OF MOLECULAR MEDICINE-JMM, v. 97, n. 6, p. 855-869, JUN 2019. (10/19200-1, 09/14027-2, 13/04913-0, 11/18718-0)

SOUSA DE LACERDA, TONIELLI CRISTINA; COSTA-SILVA, BRUNO; GIUDICE, FERNANDA SALGUEIREDO; SALLES DIAS, MARCOS VINICIOS; DE OLIVEIRA, GABRIELA PINTAR; TEIXEIRA, BIANCA LUISE; DOS SANTOS, TIAGO GOSS; MARTINS, VILMA REGINA. Prion protein binding to HOP modulates the migration and invasion of colorectal cancer cells. CLINICAL & EXPERIMENTAL METASTASIS, v. 33, n. 5, p. 441-451, JUN 2016. (12/23285-8, 13/26097-0, 10/19200-1, 09/14027-2, 11/18718-0, 11/20853-2)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

LACERDA, Tonielli Cristina Sousa de. Role of PrPC-HOP complex and extracellular vesicles in colorectal cancer. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.