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The role of PrPc-HOP complex in colon tumors

Grant number: 11/18718-0
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): December 01, 2011
Effective date (End): November 30, 2015
Field of knowledge:Biological Sciences - Biochemistry
Principal researcher:Vilma Regina Martins
Grantee:Tonielli Cristina Sousa de Lacerda
Home Institution: A C Camargo Cancer Center. Fundação Antonio Prudente (FAP). São Paulo , SP, Brazil
Associated research grant:09/14027-2 - Mechanisms associated with the function of prion protein and its ligand STI1/Hop: therapeutic approaches, AP.TEM

Abstract

Colorectal cancer is the fourth most common cancer in the world, with a high rate of mortality and morbidity. The understanding of the mechanisms underlying this disease is of considerable impact. The cellular prion protein (PrPC), well-known for its functions in the nervous system, is among the molecules with a potential role in these tumors. The activity of PrPC depends on its interaction with other proteins including the stress inducible Protein1 (STI1), or its human homologue named Hsp90/Hsp70 organizing protein (HOP). Both PrPC and STI1/HOP are linked to cell proliferation and metastasis in tumors. The signaling pathways triggered by PrPC-STI1/Hop complex depend on the STI1/HOP secretion into the extracellular space, however the mechanisms used for STI1/Hop secretion are unknown. The present proposal aims to investigate the mechanisms associated to the secretion of HOP and to understand the participation of the PrPC-HOP complex in the tumorigenic processes using in vitro and in vivo models. In addition, the significance of HOP as a biomarker in serum of patients with colorectal tumors will also be addressed. The proposed experiments should provide a new insight into the use of PrPC-Hop complex as a therapeutic target in colon cancer. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BAPTISTEILA, ANTUANI RAFAEL; LANDEMBERGER, MICHELE CHRISTINE; SALLES DIA, MARCOS VINICIOS; GIUDIC, FERNANDA SALGUEIREDO; RODRIGUES, BRUNA ROZ; COMBAS EUFRAZIO DA SILV, PETRUS PAULO; CASSINELA, EDSON KUATELELA; LACERDA, TONIELLI CRISTINA; MARCHI, FABIO ALBUQUERQUE; PAES LEME, ADRIANA FRANCO; BEGNAMI, MARIA DIRLEI; AGUIAR JR, SAMUEL; MARTINS, ILMA REGINA. Rab5C enhances resistance to ionizing radiation in rectal cancer. JOURNAL OF MOLECULAR MEDICINE-JMM, v. 97, n. 6, p. 855-869, JUN 2019. Web of Science Citations: 0.
SOUSA DE LACERDA, TONIELLI CRISTINA; COSTA-SILVA, BRUNO; GIUDICE, FERNANDA SALGUEIREDO; SALLES DIAS, MARCOS VINICIOS; DE OLIVEIRA, GABRIELA PINTAR; TEIXEIRA, BIANCA LUISE; DOS SANTOS, TIAGO GOSS; MARTINS, VILMA REGINA. Prion protein binding to HOP modulates the migration and invasion of colorectal cancer cells. CLINICAL & EXPERIMENTAL METASTASIS, v. 33, n. 5, p. 441-451, JUN 2016. Web of Science Citations: 4.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.