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Mesenchymal stem cells and platelet rich plasma associated with microfractures on the treatment of articular chondral defects in horses

Grant number: 11/19705-9
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2012
Effective date (End): March 31, 2015
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal Investigator:Ana Liz Garcia Alves
Grantee:Ana Lucia Miluzzi Yamada
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Osteoarthritis is one of the most prevalent causes of lameness in horses, and it is associated with poor performance, physical incapacity and early retirement of horses from sports. Articular cartilage is the key target of the degenerative disorders of osteoarthritis. Nowadays studies have attempted to overcome barriers of the articular cartilage repair. The bioengineering, used as a support in the standard therapies has contributed significantly not just for reduce the pain and joint deterioration, but even as an alternative therapy for regeneration. The Mesenchymal Stem Cells (MSC) has received a great importance in the treatment of osteoarthritis due to its therapeutic potential and a large immunomodulatory capacity. Similarly, the use of Platelet Rich Plasma (PRP) in animals with chondral defects has resulted in a significant decrease in pain and improvement in the rate of chondrocyte proliferation and extracellular matrix production. The use of microfractures as well supported therapy that has presented favorable results, applied in combination with the MSC and PRP, which is already known to be beneficial should still be investigated to enhance the articular cartilage repair. Therefore, the aim of this study will be to compare the effect of treatment only with microfractures to the microfractures associated with MSC and the PRP in articular cartilage defects experimentally induced by arthroscopy in the medial femoral trochlea of the patellofemoral joint of horses. This study attempts to an optimal approach to reducing the formation of fibrocartilage and reach the full recovery of the joint affected by osteoarthritis.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ANA LÚCIA M. YAMADA; MARINA L. ALVARENGA; JAQUELINE S. BRANDÃO; MARCOS J. WATANABE; CELSO A. RODRIGUES; CARLOS A. HUSSNI; ANA L.G. ALVES. Arcabouço de PRP-gel associado a células tronco mesenquimais: uso em lesões condrais em modelo experimental equino. Pesquisa Veterinária Brasileira, v. 36, n. 6, p. 461-467, Jun. 2016.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
YAMADA, Ana Lucia Miluzzi. Células-tronco mesenquimais em gel de plasma rico em plaquetas associados com microfraturas no tratamento de lesões condrais articulares em equinos. 2015. 134 f. Doctoral Thesis - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Medicina Veterinária e Zootecnia..

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