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Vascular changes of the blood-brain barrier in hypertensive animals: Effects of the aerobic exercise

Grant number: 11/14395-1
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): February 01, 2012
Effective date (End): November 30, 2015
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal researcher:Lisete Compagno Michelini
Grantee:Leila Buttler
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Despite the intensive research and therapeutic advances made within the last decades, the arterial hypertension is still the main problem of the world health. The hypertension causes changes in the central nervous system (CNS) like, for example, the increase in the blood-brain barrier (BBB) permeability and its consequent disruption, which are important factors of risk for stroke. So, the integrity of the BBB is essential for the CNS homeostasis. The mechanisms of which the hypertension affects the BBB function are still to be determined and a lot of questions remain to be answered. It's known that the angiotensin II (ANG II) has an important role on the BBB disruption, directly modulating the function of the endothelial cells and changing its permeability, through the AT1 receptors, rise on the oxidative stress and inflammation. Experiments in our laboratory have been demonstrating that the low intensity aerobic training is an efficient therapeutic method to reduce the expression and activity of the brain renin-angiotensin system (RAS). Thus, we pretend to investigate the effects of the aerobic training on the permeability of the BBB (extravasation of the fluorescent dye to the encephalic extravascular space, through the immunohistochemistry technique), over the health BBB constituent proteins expression (endothelial barrier antigen and transferrin receptor) and damaged (dysferin, lesion marker), as well to evaluate the expression of AT1 and inflammatory markers (tumoral necrose factor alfa - TNF± - and interleucin 6 - IL-6), with the western-blotting method.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BUTTLER, LEILA; JORDAO, MARIA T.; FRAGAS, MATHEUS G.; RUGGERI, ADRIANA; CERONI, ALEXANDRE; MICHELINI, LISETE C. Maintenance of Blood-Brain Barrier Integrity in Hypertension: A Novel Benefit of Exercise Training for Autonomic Control. FRONTIERS IN PHYSIOLOGY, v. 8, DEC 12 2017. Web of Science Citations: 11.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
. Blood brain barrier dysfunction in SHR is normalized by low to moderate intensity exercise training.. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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