Blood brain barrier dysfunction in SHR is normalized by low to moderate intensity exercise training.

Author(s)

Leila Buttler

• Document type: Doctoral Thesis
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
• Defense date: 2016-08-17

Examining board members

Lisete Compagno Michelini; Ruy Ribeiro de Campos Junior; Newton Sabino Canteras; Edilamar Menezes de Oliveira; Andréa da Silva Torrão

• Advisor: Lisete Compagno Michelini

Abstract

The arterial hypertension is accompanied by important autonomic dysfunction and blood-brain barrier (BBB) lesion while aerobic training (T) in hypertension strongly decreases the BBB lesion, maintaining its integrity on the PVN, NTS and RVLM even in the persistence of high blood pressure (BP) levels. This early response to T (2 weeks) is conditioned by the reduction of ANGII availability, increased expression of astrocytic podocytes and deactivation of the microglia in brain areas. These responses occurred simultaneously with the reduction of vasomotor sympathetic activity (2 weeks) and before the increase of both heart rate variability and parasympathetic activity, resting bradycardia and partial BP fall, appearing only at the 4th week. Changes on the BBB permeability in hypertension (lesion with structural/functional damage) and trained (maintenance of the structural/ functional integrity) are important factors to condition the autonomic dysfunction in hypertension or its correction by the training, respectively. (AU)

• FAPESP's process: 11/14395-1 - Vascular changes of the blood-brain barrier in hypertensive animals: Effects of the aerobic exercise
• Grantee: Leila Buttler
• Support Opportunities: Scholarships in Brazil - Doctorate