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Structural characterization of amphiphilic systems with industrial application using small angle X ray scattering and complementary techniques

Grant number: 11/19952-6
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): January 01, 2012
Effective date (End): December 31, 2015
Field of knowledge:Physical Sciences and Mathematics - Physics
Principal Investigator:Alexandre Magnus Gomes Carvalho
Grantee:Antonio Augusto Malfatti Gasperini
Home Institution: Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Ministério da Ciência, Tecnologia, Inovações e Comunicações (Brasil). Campinas , SP, Brazil
Associated scholarship(s):13/13149-2 - Techniques for Langmuir monolayer characterization using synchrotron radiation, BE.EP.PD

Abstract

This project proposes the study of small angle X ray scattering (SAXS), with and without grazing incidence, of liposome dispersions and lipid multilayers which have application on the pharmaceutical industry. The experiments will be performed at the SAXS beamline at the Synchrotron Light National Lab (LNLS). For the experiments using SAXS with grazing incidence (GISAXS), one chamber with humidity control will be designed to be coupled to an existing goniometer, which is in commissioning phase. The data analysis will be done using modeling programs developed specifically for liposome dispersions and lipid multilayers, which will also be useful for other ongoing projects at the small angle scattering group (ERX) at LNLS. The development of the present project will bring benefits not only to the ERX group, in which the candidate will start his activities, but also to the users' community of the SAXS beamline at LNLS which will make use of the commissioned setup for GISAXS with isolated chamber. Other techniques, like electron microscopy, Langmuir monolayers and grazing incidence diffraction (GID) are proposed as a perspective for continuing this project.

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PUSTERLA, JULIO M.; MALFATTI-GASPERINI, ANTONIO A.; PUENTES-MARTINEZ, XIMENA E.; CAVALCANTI, LEIDE P.; OLIVEIRA, RAFAEL G. Refractive index and thickness determination in Langmuir monolayers of myelin lipids. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1859, n. 5, p. 924-930, MAY 2017. Web of Science Citations: 9.
BALBINO, TIAGO A.; SERAFIN, JULIANA M.; MALFATTI-GASPERINI, ANTONIO A.; DE OLIVEIRA, CRISTIANO L. P.; CAVALCANTI, LEIDE P.; DE JESUS, MARCELO B.; DE LA TORRE, LUCIRNARA G. Microfluidic Assembly of pDNA/Cationic Liposome Lipoplexes with High pDNA Loading for Gene Delivery. Langmuir, v. 32, n. 7, p. 1799-1807, FEB 23 2016. Web of Science Citations: 11.
LI-DESTRI, G.; TUMMINO, A.; MALFATTI GASPERINI, A. A.; MONREAL, L. PARELLADA; MESSINA, G. M. L.; SPAMPINATO, V.; CECCONE, G.; KONOVALOV, O. Filling nanoporous polymer thin films: an easy route toward the full control of the 3D nanostructure. RSC ADVANCES, v. 6, n. 11, p. 9175-9179, 2016. Web of Science Citations: 1.
LI DESTRI, GIOVANNI; MALFATTI GASPERINI, ANTONIO A.; KONOVALOV, OLEG. The Link Between Self-Assembly and Molecular Conformation of Amphiphilic Block Copolymers Monolayers at the Air/Water Interface: The Spreading Parameter. Langmuir, v. 31, n. 32, p. 8856-8864, AUG 18 2015. Web of Science Citations: 19.
GASPERINI, ANTONIO A. M.; PUENTES-MARTINEZ, XIMENA E.; BALBINO, TIAGO ALBERTINI; RIGOLETTO, THAIS DE PAULA; CAVALCANTI CORREA, GABRIELA DE SA; CASSAGO, ALEXANDRE; PORTUGAL, RODRIGO VILLARES; DE LA TORRE, LUCIMARA GAZIOLA; CAVALCANTI, LEIDE P. Association between Cationic Liposomes and Low Molecular Weight Hyaluronic Acid. Langmuir, v. 31, n. 11, p. 3308-3317, MAR 24 2015. Web of Science Citations: 12.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.