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ALVEOLAR HEALING PROCESS AFTER TOOTH EXTRACTION AND FILLING OF DENTAL SOCKET WITH BIOMATERIAL INORGANIC BOVINE. A histological and histometric study in rats.

Grant number: 11/20869-6
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2012
Effective date (End): December 31, 2013
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal researcher:Daniela Ponzoni
Grantee:Agnes Soares de Sampaio Nascimento
Home Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

Several biomaterias bovine arise in national market to be used in the dental clinic. The behavior of these materials need to be evaluated within bone cavities in animals for histological observations of your repair potential generation of foreign body reactions. The dental alveolus is a bone cavity that has peculiarities in its repair process. The alveolar repair process should culminate in the formation of bone tissue inside to future implant rehabilitations osseointegráveis or through conventional prostheses. When any of the alveolar walls is damaged, there is the need for reconstruction and for this, one of the options is the use of biomaterials. The bovine biomaterials are available and do not require access to donor areas of patients, although is expected of them only on the potential osteocondutor. This work aims to analyze the dynamics of repair of wells filled with clot linen and with biomaterial inorganic beef (BoneFill ®) in rats through histological and histometric analysis. For both will be used 32 male Wistar rats, weighing between 200-240 divided into 2 groups: Group I (16, control group rats), group II (test group, 16 animals). All animals have the right upper incisor extracted. Animals in the control group will be well populated with linen clot. In the treated group animals will have the dental socket populated by granules of biomaterial. All animals have the dental socket sutured together with silk thread 4.0. The experimental periods shall be 14 and 28 days post-op. Histological analysis will be carried out qualitative and quantitative. The histometric analysis will be held on two identical sizes fields located in the middle third of lingual alveolar. The average percentage of new bone tissue will undergo statistical tests to assess whether there were differences between the experimental groups evaluated (p 0.05 <). It is expected that this composition of material can effectively act as a driver of bone formation in the dental alveoli and do not generate significant foreign body reactions.

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