| Grant number: | 11/13161-7 |
| Support Opportunities: | Scholarships in Brazil - Master |
| Start date: | March 01, 2012 |
| End date: | April 30, 2013 |
| Field of knowledge: | Health Sciences - Pharmacy - Toxicological Analysis |
| Principal Investigator: | Marina Franco Maggi Tavares |
| Grantee: | Lucas André Lobo Gomes |
| Host Institution: | Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
Abstract Cocaine use has been studied for decades for the damage it causes both to the person and to society. According to ONU, Brazil is the major cocaine market in South America and also has the second place in all America, only behind the US. Although, most studies about cocaine are focused in the severe binge toxicity, leaving prevalent non-abusive users out of focus to latent generated damage. I order to create a screening method covering a several substances, metabolomics enters to help toxicology with the global metabolite analysis in biofluids in order to generate a comprehensive alteration map of this toxic. Several sensitive methods are recommended in literature, but none of them are able to perform a global analysis of endogenous metabolites or, specifically, cocaine and all his five metabolites in only one analysis. Due to his high resolving power, capillary electrophoresis (CE) has gained popularity within the forensic setting. In particular, its coupling with mass spectrometry (MS) allows the analysis of virtually all classes of compounds, as recommended in studies involving complex biological samples. In this work, the metabolomic alterations caused by cocaine in several doses will be assessed in mice urine samples, using CE-MS as an analytical tool, in a systematic way. | |
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