Design, synthesis and evaluation of antimicrobial activity of novel furfuryliden derivatives against nosocomial infections.

• Grant number: 11/14773-6
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2012
• End date: November 30, 2013
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Leoberto Costa Tavares
• Grantee: Rodrigo Rocha Zorzi
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Nosocomial infections are caused by fungis or bacteria and are the cause of millions of deaths every year. The primary aim are pacients with low immunity, like immunosuppressed and persons in the age extreme. Today, with the rising of resistant nosocomial infections, mainly because of the excess of antibiotics prescription, the research for new drugs is crucial, and the nitrocompounds, especially nifuroxazida analogs, showed a potential activity. This project proposes the design, synthesis, evaluation of antimicrobial activity and molecular modeling studies of novel furfuryliden and oxadiazolines derivatives against several nosocomial infections.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ZORZI, Rodrigo Rocha. Design, synthesis and evaluation of antimicrobial activity of novel furfuryliden derivatives against nosocomial infections. 2013. Master's Dissertation - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.