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Investigation of toxicity of the commercial herbicide 2,4-D using gills of tilapia as a model

Grant number: 11/14881-3
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): February 28, 2014
Field of knowledge:Biological Sciences - Morphology - Histology
Principal Investigator:Carmem Silvia Fontanetti Christofoletti
Grantee:Ana Claudia de Castro Marcato
Host Institution: Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil


Water is an essential factor for maintaining the vital functions of living beings. It has been observed a growing commitment of its quality due to pollution from many sources and even entire watersheds, whether its by industrial waste, sewage, or, by substances used in agriculture such as pesticides, herbicides and fertilizers. For over 50 years, 2,4-dichlorophenoxyacetic acid (2,4-D) is used worldwide, among these uses, one was its use as one of the compounds of "Agent Orange" used in the Vietnam War. Due to the fact that its genotoxicity and its long persistence in soil have been proved by several studies, which allows the leaching and percolation of the compound affecting water bodies, studies of its toxicity are relevant and justifiable. Fishes are excellent experimental models for studies of aquatic toxicology, since they warn about the potential danger of chemicals or the possibility of environmental pollution. Given the above, this project aims to determine the consequences of the presence of the commercial herbicide 2,4-D in the aquatic environment, using gills of Oreochromis niloticus (Nile tilapia), by ultra-morphology, histological and histochemical analyses. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARCATO, A. C. C.; YABUKI, A. T.; FONTANETTI, C. S.. Nickel exposure promotes osmoregulatory disturbances in Oreochromis niloticus gills: histopathological and energy dispersive spectrometry analysis. Environmental Science and Pollution Research, v. 21, n. 22, p. 13095-13102, . (11/14881-3)
DE CASTRO MARCATO, ANA CLAUDIA; DE SOUZA, CLEITON PEREIRA; FONTANETTI, CARMEM SILVIA. Herbicide 2,4-D: A Review of Toxicity on Non-Target Organisms. WATER AIR AND SOIL POLLUTION, v. 228, n. 3, . (14/23919-2, 11/14881-3, 12/50197-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MARCATO, Ana Claudia de Castro. Investigação da toxicidade e da capacidade de recuperação do herbicida 2,4-D comercial (2,4-diclorofenoxiacético) empregando brânquias de tilápias, Oreochromis niloticus, como biomarcador. 2014. Master's Dissertation - Universidade Estadual Paulista (Unesp). Instituto de Biociências. Rio Claro Rio Claro.

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