Identification and study of genes associated to the dystrophic phenotype

• Grant number: 11/15543-4
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2012
• End date: July 31, 2013
• Field of knowledge: Biological Sciences - Genetics - Human and Medical Genetics
• Principal Investigator: Mariz Vainzof
• Grantee: Camila de Freitas Almeida
• Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 98/14254-2 - The Human Genome Research Center, AP.CEPID

Abstract

The muscular dystrophies form a heterogeneous group of genetic disorders, ranging from mild to severe forms. Furthermore, it is observed phenotypic variability in carriers of an identical genetic form, the same mutation, and even between patients from the same family. This raises questions about genes that have roles in different genic networks and that may count to the pathological process, making it worse or better. The identification of these genes, already or not known, is valuable for a global comprehension of muscular dystrophies and also can reveal new avenues to therapeutic approaches.In this way, the aims of this project are to analyze the gene expression in the mice muscle tissue - Dmdmdx, Dmdmdx/Largemyd+/- e Dmdmdx/Largemyd - in various stages of disease progression using microarray technology; screen differentially expressed genes candidates for modulation/modification of the dystrophic phenotype and evaluate the genes' function in the context of the disease.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ALMEIDA, Camila de Freitas. Identification and study of differentially expressed genes in mouse models for muscular dystrophy. 2014. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Biociências (IBIOC/SB) São Paulo.