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Analysis of gene expression profile in medulloblastoma development and its relationship to patients clinical outcome

Grant number: 11/16221-0
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): February 28, 2013
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Silvia Regina Caminada de Toledo
Grantee:Bruna Mascaro Cordeiro de Azevedo
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Medulloblastoma (MB) is a embryonic neuroepithelial tumor that represents approximately 16 to 25% of all central nervous system tumors of childhood. Resistance to treatment and recurrence of the tumor are often associated with the presence of tumor stem cells, which are determinants of poor prognosis. The MB has its origin in the cerebellum and is derived from cerebellar granule cell precursors, with the appearance of stem or progenitor cells. Like stem cells, tumor cells are widely considered able to proliferate indefinitely, a capability that is caused by dysregulation of key signaling pathways. These pathways have a role in the development, for example, the Hedgehog (Hh), Wnt and Notch pathways. Recent studies have revealed that the prognosis and treatment of MB depend on the origin of tumor cells, pathways and genes involved in activation and deactivation of these cells. Thus, current targeted therapies have been based on small molecules for specific signaling pathways altered in the oncogenic process of MB.This study will investigate the gene expression profile of GLI1, PTCH1, CTNNB1, APC, HES1 and NOTCH2 genes in 40 samples of MB and the molecular findings will be correlated to the clinical data of patients.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CORDEIRO, BRUNA MASCARO; OLIVEIRA, INDHIRA DIAS; DE SEIXAS ALVES, MARIA TERESA; SABA-SILVA, NASJLA; CAPELLANO, ANDREA M.; CAVALHEIRO, SERGIO; DASTOLI, PATRICIA; CAMINADA TOLEDO, SILVIA REGINA. SHH, WNT, and NOTCH pathways in medulloblastoma: when cancer stem cells maintain self-renewal and differentiation properties. CHILD'S NERVOUS SYSTEM, v. 30, n. 7, p. 1165-1172, JUL 2014. Web of Science Citations: 17.
CRUZ, GABRIELA RAMPAZZO; OLIVEIRA, INDHIRA DIAS; MORAES, LAIS; PANIAGO, MARIO DEL GIUDICE; DE SEIXAS ALVES, MARIA TERESA; CAPELLANO, ANDREA MARIA; SABA-SILVA, NASJLA; CAVALHEIRO, SERGIO; CERUTTI, JANETE MARIA; CAMINADA TOLEDO, SILVIA REGINA. Analysis of KIAA1549-BRAF fusion gene expression and IDH1/IDH2 mutations in low grade pediatric astrocytomas. JOURNAL OF NEURO-ONCOLOGY, v. 117, n. 2, p. 235-242, APR 2014. Web of Science Citations: 19.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.