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Effects of different stressors on addiction extinction and reinstatement in animal models

Grant number: 11/16580-0
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): February 28, 2014
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Monica Levy Andersen
Grantee:Laís Fernanda Berro
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


Drug dependence is a chronic relapsing illness affected by multiple social, individual and biological factors that significantly impact its course and recovery. Stress interacts with these factors, increasing addiction relapse risk and playing a significant role in all phases of the disease, being withdrawal and relapse the most important ones for therapeutic approaches. In this scenario, researches with animal models relating translational stressors, such as social isolation and sleep deprivation, to the extinction and reinstatement of addictive behaviors can provide important pathophysiological findings and potential therapeutic approaches. We propose in the present study to investigate possible alterations caused by these two stressors in these addiction phases using sensitization and conditioned place preference as animal models of drug dependence. A possible participation of social isolation- and sleep deprivation-induced corticosterone release enhancement will be also evaluated through metyrapone (corticosterone synthesis inhibitor) and exogenous corticosterone administration. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BERRO, L. F.; SANTOS, R.; HOLLAIS, A. W.; WUO-SILVA, R.; FUKUSHIRO, D. F.; MARI-KAWAMOTO, E.; COSTA, J. M.; TROMBIN, T. F.; PATTI, C. L.; GRAPIGLIA, S. B.; TUFIK, S.; ANDERSEN, M. L.; FRUSSA-FILHO, R. Acute total sleep deprivation potentiates cocaine-induced hyperlocomotion in mice. Neuroscience Letters, v. 579, p. 130-133, SEP 5 2014. Web of Science Citations: 7.
BERRO, L. F.; HOLLAIS, A. W.; PATTI, C. L.; FUKUSHIRO, D. F.; MARI-KAWAMOTO, E.; TALHATI, F.; COSTA, J. M.; ZANIN, K. A.; LOPES-SILVA, L. B.; CECCON, L. M.; SANTOS, R.; PROCOPIO-SOUZA, R.; TROMBIN, T. F.; YOKOYAMA, T. S.; WUO-SILVA, R.; TUFIK, S.; ANDERSEN, M. L.; FRUSSA-FILHO, R. Sleep deprivation impairs the extinction of cocaine-induced environmental conditioning in mice. Pharmacology Biochemistry and Behavior, v. 124, p. 13-18, SEP 2014. Web of Science Citations: 10.
BERRO, LAIS F.; FRUSSA-FILHO, ROBERTO; TUFIK, SERGIO; ANDERSEN, MONICA L. Relationships between sleep and addiction: The role of drug-environment conditioning. Medical Hypotheses, v. 82, n. 3, p. 374-376, MAR 2014. Web of Science Citations: 4.

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