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Clinical and molecular study of fatigue and its correlation with sleep standards and quality of life in children and adolescents with cancer

Grant number: 11/17006-6
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): February 28, 2014
Field of knowledge:Health Sciences - Nursing
Principal Investigator:Milena Jorge Simões Flória Lima Santos
Grantee:Emiliana de Omena Bomfim
Home Institution: Escola de Enfermagem de Ribeirão Preto (EERP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Several studies have explored the possibility of immune system participation, by release of cytokines, on fatigue and sleep disorders in adults with cancer. However, studies in children and adolescents suffering from malignant neoplasms are scarce internationally and absent in Brazil. The objective of this research is to investigate the serum levels of proinflammatory cytokines (IL-1, IL-6, TNF-±) and assess polymorphisms of genes that encode them, in order to correlate them with fatigue and sleep patterns in children and adolescents with cancer. It is a quantitative, descriptive, and transversal study. It aims to integrate molecular and clinical research, at the context of on genomics-based healthcare. To this end, it integrates the doctorate project (FAPESP 2010/20055-6) entitled: "Evaluation of fatigue in children and adolescents with cancer and their relation with sleep patterns and quality of life." After approval by the IRB /EERP/USP, the data will be collected at the Department of Pediatrics at HCFMRP/USP. One hundred hospitalized children and adolescents will be selected to participate. After answering the scales to measure fatigue and sleep disorders, in the project mentioned above, they will have blood samples taken to measure serum levels of IL-1, IL-6, TNF-± and identify polymorphisms of genes encoding those cytokines. Descriptive statistical analysis and Pearson's correlation will be used for the correlations between clinical and laboratory data. Based on these findings it would be proposed nursing interventions that aim to minimize the suffering of young people affected by malignant neoplasms and their families.

Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BOMFIM, Emiliana de Omena. Correlationsamong pro and anti-inflammatory cytokines with fatigue, sleep patterns and life quality in children and adolescents with cancer. 2014. Master's Dissertation - Universidade de São Paulo (USP). Escola de Enfermagem de Ribeirão Preto Ribeirão Preto.

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