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Structural and functional conectivity analysis in Parkinsons Disease Patients

Grant number: 11/19958-4
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2012
Effective date (End): September 30, 2015
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Fernando Cendes
Grantee:Rachel Paes Guimarães
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated scholarship(s):13/03358-3 - Resting state functional magnetic resonance imaging in patients with Parkinson Disease and impulsivity, BE.EP.DR


Parkinson's Disease is the second most common neurodegenerative disease, and affects around 17/100.000 individuals. The most important symptoms are rigidity, rest tremor, bradicinesia, freezing and postural instability. Nowadays, the diagnose of Parkinson's Disease occurs when the first symptoms appears, usually on the fifth decade of life. Despite its incidence, the etiology is still unknown, but it is believed that genetic, environmental and endogenous factors are related.The objective of the present study is to assess brain alterations in Parkinson's Disease through Diffusion Tensor Imaging (DTI) and resting state functional magnetic resonance - rs-fMRI.Patients with Parkinson's Disease will be selected. The subjects will be submitted to a neurologic exam, application of the UPDRS scale and magnetic resonance imaging scans. Patients will be monitored for at least 12 months, and the data obtained in the assessments will be stored for statistical analysis.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GUIMARAES, RACHEL PAES; ARCI SANTOS, MARIA CRISTINA; DAGHER, ALAIN; CAMPOS, LIDIANE SOARES; AZEVEDO, PAULA; PIOVESANA, LUIZA GONZAGA; DE CAMPOS, BRUNNO MACHADO; LARCHER, KEVIN; ZEIGHAMI, YASHAR; SCARPARO AMATO-FILHO, AUGUSTO C.; et al. Pattern of Reduced Functional Connectivity and Structural Abnormalities in Parkinson's Disease: An Exploratory Study. FRONTIERS IN NEUROLOGY, v. 7, . (13/03358-3, 11/19958-4, 12/05286-7)
GUIMARAES, RACHEL P.; CAMPOS, BRUNNO M.; DE REZENDE, THIAGO J.; PIOVESANA, LUIZA; AZEVEDO, PAULA C.; AMATO-FILHO, AUGUSTO C.; CENDES, FERNANDO; D'ABREU, ANELYSSA. Is Diffusion Tensor Imaging a Good Biomarker for Early Parkinson's Disease?. FRONTIERS IN NEUROLOGY, v. 9, . (11/19958-4, 13/07559-3, 13/03358-3)
GUIMARAES, RACHEL; AZEVEDO, PAULA; PIOVESANA, LUIZA; CAMPOS, LIDIANE; CAMPOS, BRUNNO; D'ABREU, ANELYSSA; CENDES, FERNANDO. Tractography Analysis of Corticospinal Tract, Cingulum and Corpus Callosum in Parkinson's Disease. Neurology, v. 86, p. 2-pg., . (11/19958-4)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
GUIMARÃES, Rachel Paes. Structural and functional analyzes in Parkinson's disease. 2015. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.

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