| Grant number: | 11/23214-0 |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| Start date: | March 01, 2012 |
| End date: | December 31, 2015 |
| Field of knowledge: | Biological Sciences - Immunology - Cellular Immunology |
| Principal Investigator: | Anamaria Aranha Camargo |
| Grantee: | Luís Felipe Ingrassia Campesato |
| Host Institution: | Laboratório de Biologia Molecular e Genômica. Instituto Ludwig de Pesquisa sobre o Câncer (ILPC). São Paulo , SP, Brazil |
| Associated scholarship(s): | 13/24133-0 - Investigation of the role of SIGIRR/TIR8 in breast tumors and its association with the immune response using a transgenic MMTV-neu/SIGIRR-KO animal model, BE.EP.DR |
Abstract Overexpression of the oncogene ERBB2 is present in nearly 30% of breast tumors and its expression isdirectly associated with bad prognosis, although its molecular pathways are still poorly understood. In order to investigate the role of ERBB2, our research group started a project aiming the identification of genes that are modulated by ERBB2 overexpression. We detected a strong association between ERBB2 and SIGIRR expression, a gene encoding a modulatory protein involved in pro-inflammatory response triggered by IL1Rand TLR4 activation. Growing evidences point to a correlation between the number of infiltrated immune cells in solid tumors and an impact on tumorigenesis. In this microenvironment, the recruitment and polarization of immune cells are induced by tumor-secreted factors (cytokines and chemokines) which are able to supress the antitumoral immune response and to sustain tumor growth. In the present project we intend to evaluate the role of SIGIRR in tumor growth and its relation with activation and modulation ofinflammatory and immune response. | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
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