Synthesis and activity of gallic acid conjugates - GnRH-III

• Grant number: 11/17735-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: April 01, 2012
• End date: December 31, 2012
• Field of knowledge: Biological Sciences - Biochemistry - Chemistry of Macromolecules
• Principal Investigator: Eduardo Maffud Cilli
• Grantee: Júlia Pinto Piccoli
• Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

The hormone lGnRH-III (GLP-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2), an analog of the hormone GnRH, has been described as an inhibitor of tumor growth by binding to GnRH receptors, having the possibility of use in cancer therapy. In addition, gallic acid and its derivatives also show great potential biological, inducing apoptosis in tumor cells. In this paper, we propose the synthesis of conjugates containing gallic acid and the hormone-lGnRH III, in order to obtain anticancer molecules. Techniques such as peptide synthesis in solid phase (SPPS), high-performance liquid chromatography (HPLC), and amino acid analysis will be used to obtain these conjugates. Biological tests also will be performed. In short, the goal of this work is to study the feasibility of the synthesis of conjugated Gallic - lGnRH-III and Gallic- (µ-amino caproic acid)2 - lGnRH-III and check the possible increase in anticancer activity.(AU)